7KVE
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7KXY
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6V5T
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6V64
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![BU of 6v64 by Molmil](/molmil-images/mine/6v64) | Crystal structure of human thrombin bound to ppack with tryptophans replaced by 5-F-tryptophan | 分子名称: | D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, SODIUM ION, Thrombin heavy chain, ... | 著者 | Ruben, E.A, Chen, Z, Di Cera, E. | 登録日 | 2019-12-04 | 公開日 | 2020-05-13 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | 主引用文献 | 19F NMR reveals the conformational properties of free thrombin and its zymogen precursor prethrombin-2. J.Biol.Chem., 295, 2020
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7KVF
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3EE0
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![BU of 3ee0 by Molmil](/molmil-images/mine/3ee0) | Crystal Structure of the W215A/E217A Mutant of Human Thrombin (space group P2(1)2(1)2(1)) | 分子名称: | Thrombin heavy chain, Thrombin light chain | 著者 | Gandhi, P.S, Page, M.J, Chen, Z, Bush-Pelc, L, Di Cera, E. | 登録日 | 2008-09-03 | 公開日 | 2009-07-07 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Molecular Basis for the Kinetic Differences of the W215A/E217A Mutant of Human and Murine Thrombin To be Published
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3EDX
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![BU of 3edx by Molmil](/molmil-images/mine/3edx) | Crystal structure of the W215A/E217A mutant of murine thrombin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, Thrombin heavy chain, ... | 著者 | Gandhi, P.S, Page, M.J, Chen, Z, Bush-pelc, L, Di Cera, E. | 登録日 | 2008-09-03 | 公開日 | 2009-07-07 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Molecular Basis for the Kinetic Differences of the W215A/E217A Mutant of Human and Murine Thrombin To be Published
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5JNA
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![BU of 5jna by Molmil](/molmil-images/mine/5jna) | Crystal structure for the complex of human carbonic anhydrase IV and topiramate | 分子名称: | ACETATE ION, Carbonic anhydrase 4, GLYCEROL, ... | 著者 | Chen, Z, Waheed, A, Di Cera, E, Sly, W.S. | 登録日 | 2016-04-29 | 公開日 | 2017-05-03 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Intrinsic thermodynamics of high affinity inhibitor binding to recombinant human carbonic anhydrase IV. Eur. Biophys. J., 47, 2018
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6PX5
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![BU of 6px5 by Molmil](/molmil-images/mine/6px5) | CRYSTAL STRUCTURE OF HUMAN MEIZOTHROMBIN DESF1 MUTANT S195A bound with PPACK | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, Prothrombin, ... | 著者 | Pelc, L.A, Koester, S.K, Chen, Z, Gistover, N, Di Cera, E. | 登録日 | 2019-07-24 | 公開日 | 2019-09-04 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Residues W215, E217 and E192 control the allosteric E*-E equilibrium of thrombin. Sci Rep, 9, 2019
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6PXQ
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![BU of 6pxq by Molmil](/molmil-images/mine/6pxq) | Crystal structure of human thrombin mutant D194A | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Thrombin heavy chain, Thrombin light chain | 著者 | Stojanovski, B, Chen, Z, Koester, S.K, Pelc, L.A, Di Cera, E. | 登録日 | 2019-07-26 | 公開日 | 2019-12-18 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Role of the I16-D194 ionic interaction in the trypsin fold. Sci Rep, 9, 2019
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5KU6
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![BU of 5ku6 by Molmil](/molmil-images/mine/5ku6) | Crystal structure for the complex of human carbonic anhydrase IV and methazolamide | 分子名称: | ACETATE ION, Carbonic anhydrase 4, GLYCEROL, ... | 著者 | Chen, Z, Waheed, A, Di Cera, E, Sly, W.S. | 登録日 | 2016-07-12 | 公開日 | 2017-07-26 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Intrinsic thermodynamics of high affinity inhibitor binding to recombinant human carbonic anhydrase IV. Eur. Biophys. J., 47, 2018
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5JNC
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![BU of 5jnc by Molmil](/molmil-images/mine/5jnc) | Crystal structure for the complex of human carbonic anhydrase IV and 4-aminomethylbenzene sulfonamide | 分子名称: | 4-(aminomethyl)benzene-1-sulfonamide, ACETATE ION, Carbonic anhydrase 4, ... | 著者 | Chen, Z, Waheed, A, Di Cera, E, Sly, W.S. | 登録日 | 2016-04-29 | 公開日 | 2017-05-03 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Intrinsic thermodynamics of high affinity inhibitor binding to recombinant human carbonic anhydrase IV. Eur. Biophys. J., 47, 2018
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5JN9
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![BU of 5jn9 by Molmil](/molmil-images/mine/5jn9) | Crystal structure for the complex of human carbonic anhydrase IV and ethoxyzolamide | 分子名称: | 6-ethoxy-1,3-benzothiazole-2-sulfonamide, ACETATE ION, Carbonic anhydrase 4, ... | 著者 | Chen, Z, Waheed, A, Di Cera, E, Sly, W.S. | 登録日 | 2016-04-29 | 公開日 | 2017-05-03 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Intrinsic thermodynamics of high affinity inhibitor binding to recombinant human carbonic anhydrase IV. Eur. Biophys. J., 47, 2018
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5JN8
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![BU of 5jn8 by Molmil](/molmil-images/mine/5jn8) | Crystal Structure for the complex of human carbonic anhydrase IV and acetazolamide | 分子名称: | 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, ACETATE ION, Carbonic anhydrase 4, ... | 著者 | Chen, Z, Waheed, A, Di Cera, E, Sly, W.S. | 登録日 | 2016-04-29 | 公開日 | 2017-05-03 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Intrinsic thermodynamics of high affinity inhibitor binding to recombinant human carbonic anhydrase IV. Eur. Biophys. J., 47, 2018
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3HK3
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![BU of 3hk3 by Molmil](/molmil-images/mine/3hk3) | Crystal structure of murine thrombin mutant W215A/E217A (one molecule in the asymmetric unit) | 分子名称: | Thrombin heavy chain, Thrombin light chain | 著者 | Gandhi, P.S, Page, M.J, Chen, Z, Bush-Pelc, L, Di Cera, E. | 登録日 | 2009-05-22 | 公開日 | 2009-07-07 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Mechanism of the Anticoagulant Activity of Thrombin Mutant W215A/E217A. J.Biol.Chem., 284, 2009
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3HK6
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![BU of 3hk6 by Molmil](/molmil-images/mine/3hk6) | Crystal structure of murine thrombin mutant W215A/E217A (two molecules in the asymmetric unit) | 分子名称: | Thrombin heavy chain, Thrombin light chain | 著者 | Gandhi, P.S, Page, M.J, Chen, Z, Bush-Pelc, L, Di Cera, E. | 登録日 | 2009-05-22 | 公開日 | 2009-07-07 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Mechanism of the Anticoagulant Activity of Thrombin Mutant W215A/E217A. J.Biol.Chem., 284, 2009
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3HKI
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![BU of 3hki by Molmil](/molmil-images/mine/3hki) | Crystal structure of murine thrombin mutant W215A/E217A in complex with the extracellular fragment of human PAR1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Proteinase-activated receptor 1, Thrombin heavy chain, ... | 著者 | Gandhi, P.S, Page, M.J, Chen, Z, Bush-Pelc, L, Di Cera, E. | 登録日 | 2009-05-23 | 公開日 | 2009-07-07 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Mechanism of the Anticoagulant Activity of Thrombin Mutant W215A/E217A. J.Biol.Chem., 284, 2009
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3HKJ
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![BU of 3hkj by Molmil](/molmil-images/mine/3hkj) | Crystal structure of human thrombin mutant W215A/E217A in complex with the extracellular fragment of human PAR1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Proteinase-activated receptor 1, Thrombin heavy chain, ... | 著者 | Gandhi, P.S, Page, M.J, Chen, Z, Bush-Pelc, L, Di Cera, E. | 登録日 | 2009-05-23 | 公開日 | 2009-07-07 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Mechanism of the Anticoagulant Activity of Thrombin Mutant W215A/E217A. J.Biol.Chem., 284, 2009
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6PXJ
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![BU of 6pxj by Molmil](/molmil-images/mine/6pxj) | Crystal structure of human thrombin mutant I16T | 分子名称: | GLYCEROL, MAGNESIUM ION, Thrombin heavy chain, ... | 著者 | Stojanovski, B, Chen, Z, Koester, S.K, Pelc, L.A, Di Cera, E. | 登録日 | 2019-07-26 | 公開日 | 2019-12-18 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Role of the I16-D194 ionic interaction in the trypsin fold. Sci Rep, 9, 2019
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2FMJ
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1SHH
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![BU of 1shh by Molmil](/molmil-images/mine/1shh) | Slow form of Thrombin Bound with PPACK | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, thrombin | 著者 | Pineda, A.O, Carrell, C.J, Bush, L.A, Prasad, S, Caccia, S, Chen, Z.W, Mathews, F.S, Di Cera, E. | 登録日 | 2004-02-25 | 公開日 | 2004-06-08 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Molecular dissection of na+ binding to thrombin. J.Biol.Chem., 279, 2004
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1T32
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![BU of 1t32 by Molmil](/molmil-images/mine/1t32) | A Dual Inhibitor of the Leukocyte Proteases Cathepsin G and Chymase with Therapeutic Efficacy in Animals Models of Inflammation | 分子名称: | 2-[3-({METHYL[1-(2-NAPHTHOYL)PIPERIDIN-4-YL]AMINO}CARBONYL)-2-NAPHTHYL]-1-(1-NAPHTHYL)-2-OXOETHYLPHOSPHONIC ACID, Cathepsin G, SULFATE ION | 著者 | de Garavilla, L, Greco, M.N, Giardino, E.C, Wells, G.I, Haertlein, B.J, Kauffman, J.A, Corcoran, T.W, Derian, C.K, Eckardt, A.J, Abraham, W.M, Sukumar, N, Chen, Z, Pineda, A.O, Mathews, F.S, Di Cera, E, Andrade-Gordon, P, Damiano, B.P, Maryanoff, B.E. | 登録日 | 2004-04-23 | 公開日 | 2005-03-01 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and anti-inflammatory activity in vivo. J.Biol.Chem., 280, 2005
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2HWL
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![BU of 2hwl by Molmil](/molmil-images/mine/2hwl) | Crystal structure of thrombin in complex with fibrinogen gamma' peptide | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fibrinogen gamma' peptide, Prothrombin, ... | 著者 | Pineda, A.O, Chen, Z.W, Marino, F, Mathews, F.S, Mosesson, M.W, Di Cera, E. | 登録日 | 2006-08-01 | 公開日 | 2006-09-19 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structure of thrombin in complex with fibrinogen gamma' peptide. Biophys.Chem., 125, 2007
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2HVX
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![BU of 2hvx by Molmil](/molmil-images/mine/2hvx) | Discovery of Potent, Orally Active, Nonpeptide Inhibitors of Human Mast Cell Chymase by Using Structure-Based Drug Design | 分子名称: | Chymase, [(1S)-1-(5-CHLORO-1-BENZOTHIEN-3-YL)-2-(2-NAPHTHYLAMINO)-2-OXOETHYL]PHOSPHONIC ACID | 著者 | Greco, M.N, Hawkins, M.J, Powell, E.T, Almond, H.R, de Garavilla, L, Wang, Y, Minor, L.A, Wells, G.I, Di Cera, E, Cantwell, A.M, Savvides, S.N, Damiano, B.P, Maryanoff, B.E. | 登録日 | 2006-07-31 | 公開日 | 2007-06-12 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase. J.Med.Chem., 50, 2007
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3SQE
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![BU of 3sqe by Molmil](/molmil-images/mine/3sqe) | |