6PX5

CRYSTAL STRUCTURE OF HUMAN MEIZOTHROMBIN DESF1 MUTANT S195A bound with PPACK

Summary for 6PX5

• Entry DOI: 10.2210/pdb6px5/pdb
• Related: 3e6p
• Related PRD ID: PRD_000020
• Descriptor: Prothrombin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (7 entities in total)
• Functional Keywords: hydrolase, serine protease, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 47745.83

Authors

Pelc, L.A.,Koester, S.K.,Chen, Z.,Gistover, N.,Di Cera, E. (deposition date: 2019-07-24, release date: 2019-09-04, Last modification date: 2023-10-11)

• Primary citation: Pelc, L.A.,Koester, S.K.,Chen, Z.,Gistover, N.E.,Di Cera, E.; Residues W215, E217 and E192 control the allosteric E*-E equilibrium of thrombin.; Sci Rep, 9:12304-12304, 2019; PubMed: 31444378; DOI: 10.1038/s41598-019-48839-1

Experimental method

X-RAY DIFFRACTION (2.4 Å)