6PX5
CRYSTAL STRUCTURE OF HUMAN MEIZOTHROMBIN DESF1 MUTANT S195A bound with PPACK
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | X | Prothrombin | polymer | 152 | 16949.4 | 1 | UniProt (P00734) Pfam (PF00051) Pfam (PF09396) In PDB | Homo sapiens (Human) | Coagulation factor II |
| 2 | B | Prothrombin | polymer | 259 | 29764.2 | 1 | UniProt (P00734) Pfam (PF00089) In PDB | Homo sapiens (Human) | Coagulation factor II |
| 3 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 4 | X | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | B | D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide | non-polymer | 454.0 | 1 | BIRD (PRD_000020) Chemie (0G6) | |||
| 6 | B | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 7 | water | water | 18.0 | 53 | Chemie (HOH) |
Sequence modifications
B: 16 - 247 (UniProt: P00734)
| PDB | External Database | Details |
|---|---|---|
| Ala 195 | Ser 568 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 46713.6 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 607.8 | |
| All* | Total formula weight | 47745.8 |
