5JN9

Crystal structure for the complex of human carbonic anhydrase IV and ethoxyzolamide

Summary for 5JN9

Entry DOI	10.2210/pdb5jn9/pdb
Related	5JN8 5JNA 5JNC 5JND
Descriptor	Carbonic anhydrase 4, ZINC ION, 6-ethoxy-1,3-benzothiazole-2-sulfonamide, ... (7 entities in total)
Functional Keywords	carbonic anhydrase, lyase, inhibitor binding, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	124007.76
Authors	Chen, Z.,Waheed, A.,Di Cera, E.,Sly, W.S. (deposition date: 2016-04-29, release date: 2017-05-03, Last modification date: 2023-09-27)
Primary citation	Mickeviciute, A.,Timm, D.D.,Gedgaudas, M.,Linkuviene, V.,Chen, Z.,Waheed, A.,Michailoviene, V.,Zubriene, A.,Smirnov, A.,Capkauskaite, E.,Baranauskiene, L.,Jachno, J.,Revuckiene, J.,Manakova, E.,Grazulis, S.,Matuliene, J.,Di Cera, E.,Sly, W.S.,Matulis, D. Intrinsic thermodynamics of high affinity inhibitor binding to recombinant human carbonic anhydrase IV. Eur. Biophys. J., 47:271-290, 2018 Cited by PubMed: 28975383 DOI: 10.1007/s00249-017-1256-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation