Crystal structure of the W215A/E217A mutant of murine thrombin

Summary for 3EDX

Related1TQ0 3EE0
DescriptorThrombin light chain, Thrombin heavy chain, SULFATE ION, ... (5 entities in total)
Functional Keywordsserine protease, acute phase, blood coagulation, cleavage on pair of basic residues, gamma-carboxyglutamic acid, glycoprotein, hydrolase, kringle, protease, zymogen
Biological sourceMus musculus (mouse)
Total number of polymer chains6
Total molecular weight106039.64
Gandhi, P.S.,Page, M.J.,Chen, Z.,Bush-pelc, L.,Di Cera, E. (deposition date: 2008-09-03, release date: 2009-07-07, Last modification date: 2020-07-29)
Primary citation
Gandhi, P.S.,Page, M.J.,Chen, Z.,Bush-Pelc, L.,Di Cera, E.
Molecular Basis for the Kinetic Differences of the W215A/E217A Mutant of Human and Murine Thrombin
To be Published,
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.24316 1.8% 3.4% 7.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-09-16