3EE0

Crystal Structure of the W215A/E217A Mutant of Human Thrombin (space group P2(1)2(1)2(1))

Summary for 3EE0

Related1TQ0 3EDX
DescriptorThrombin light chain, Thrombin heavy chain (2 entities in total)
Functional Keywordsserine protease, acute phase, blood coagulation, calcium, cleavage on pair of basic residues, disease mutation, gamma-carboxyglutamic acid, glycoprotein, hydrolase, kringle, pharmaceutical, polymorphism, protease, secreted, zymogen
Biological sourceHomo sapiens (human)
Cellular locationSecreted, extracellular space P00734 P00734
Total number of polymer chains2
Total molecular weight33703.59
Authors
Gandhi, P.S.,Page, M.J.,Chen, Z.,Bush-Pelc, L.,Di Cera, E. (deposition date: 2008-09-03, release date: 2009-07-07, Last modification date: 2011-07-13)
Primary citation
Gandhi, P.S.,Page, M.J.,Chen, Z.,Bush-Pelc, L.,Di Cera, E.
Molecular Basis for the Kinetic Differences of the W215A/E217A Mutant of Human and Murine Thrombin
To be Published,
Experimental method
X-RAY DIFFRACTION (2.75 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.324251.9%7.1%7.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution