3EE0

Crystal Structure of the W215A/E217A Mutant of Human Thrombin (space group P2(1)2(1)2(1))

Summary for 3EE0

• Entry DOI: 10.2210/pdb3ee0/pdb
• Related: 1TQ0 3EDX
• Descriptor: Thrombin light chain, Thrombin heavy chain (2 entities in total)
• Functional Keywords: serine protease, acute phase, blood coagulation, calcium, cleavage on pair of basic residues, disease mutation, gamma-carboxyglutamic acid, glycoprotein, hydrolase, kringle, pharmaceutical, polymorphism, protease, secreted, zymogen
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted, extracellular space: P00734 P00734
• Total number of polymer chains: 2
• Total formula weight: 33703.59

Authors

Gandhi, P.S.,Page, M.J.,Chen, Z.,Bush-Pelc, L.,Di Cera, E. (deposition date: 2008-09-03, release date: 2009-07-07, Last modification date: 2023-08-30)

• Primary citation: Gandhi, P.S.,Page, M.J.,Chen, Z.,Bush-Pelc, L.,Di Cera, E.; Molecular Basis for the Kinetic Differences of the W215A/E217A Mutant of Human and Murine Thrombin; To be Published,

Experimental method

X-RAY DIFFRACTION (2.75 Å)