3EDX
Crystal structure of the W215A/E217A mutant of murine thrombin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E (A, C, E) | Thrombin light chain | polymer | 44 | 5105.7 | 3 | UniProt (P19221) Pfam (PF09396) | Mus musculus (mouse) | |
| 2 | B, D, F (B, D, F) | Thrombin heavy chain | polymer | 258 | 29795.5 | 3 | UniProt (P19221) Pfam (PF00089) | Mus musculus (mouse) | |
| 3 | G, H, J, K, L... (B, D, F) | SULFATE ION | non-polymer | 96.1 | 7 | Chemie (SO4) | |||
| 4 | I, M, P (B, D, F) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 5 | Q, R, S, T, U... (A, B, C, D, E...) | water | water | 18.0 | 227 | Chemie (HOH) |
Sequence modifications
B, D, F: 16 - 246 (UniProt: P19221)
| PDB | External Database | Details |
|---|---|---|
| Ala 215 | Trp 587 | engineered mutation |
| Ala 217 | Glu 589 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 104703.6 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1336.1 | |
| All* | Total formula weight | 106039.6 |
