2HVX

Discovery of Potent, Orally Active, Nonpeptide Inhibitors of Human Mast Cell Chymase by Using Structure-Based Drug Design

Summary for 2HVX

Entry DOI	10.2210/pdb2hvx/pdb
Descriptor	Chymase, [(1S)-1-(5-CHLORO-1-BENZOTHIEN-3-YL)-2-(2-NAPHTHYLAMINO)-2-OXOETHYL]PHOSPHONIC ACID (3 entities in total)
Functional Keywords	serine protease, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Secreted: P23946
Total number of polymer chains	1
Total formula weight	25423.69
Authors	Greco, M.N.,Hawkins, M.J.,Powell, E.T.,Almond, H.R.,de Garavilla, L.,Wang, Y.,Minor, L.A.,Wells, G.I.,Di Cera, E.,Cantwell, A.M.,Savvides, S.N.,Damiano, B.P.,Maryanoff, B.E. (deposition date: 2006-07-31, release date: 2007-06-12, Last modification date: 2021-10-20)
Primary citation	Greco, M.N.,Hawkins, M.J.,Powell, E.T.,Almond, H.R.,de Garavilla, L.,Hall, J.,Minor, L.K.,Wang, Y.,Corcoran, T.W.,Di Cera, E.,Cantwell, A.M.,Savvides, S.N.,Damiano, B.P.,Maryanoff, B.E. Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase. J.Med.Chem., 50:1727-1730, 2007 Cited by PubMed: 17361995 DOI: 10.1021/jm0700619 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation