Crystal structure for the complex of human carbonic anhydrase IV and topiramate

Summary for 5JNA

Related5JN8 5JN9 5JNC 5JND
DescriptorCarbonic anhydrase 4, ZINC ION, [(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate, ... (7 entities in total)
Functional Keywordscarbonic anhydrase, lyase, zinc, inhibitor binding, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains4
Total molecular weight124298.89
Chen, Z.,Waheed, A.,Di Cera, E.,Sly, W.S. (deposition date: 2016-04-29, release date: 2017-05-03, Last modification date: 2019-02-06)
Primary citation
Mickeviciute, A.,Timm, D.D.,Gedgaudas, M.,Linkuviene, V.,Chen, Z.,Waheed, A.,Michailoviene, V.,Zubriene, A.,Smirnov, A.,Capkauskaite, E.,Baranauskiene, L.,Jachno, J.,Revuckiene, J.,Manakova, E.,Grazulis, S.,Matuliene, J.,Di Cera, E.,Sly, W.S.,Matulis, D.
Intrinsic thermodynamics of high affinity inhibitor binding to recombinant human carbonic anhydrase IV.
Eur. Biophys. J., 47:271-290, 2018
PubMed: 28975383 (PDB entries with the same primary citation)
DOI: 10.1007/s00249-017-1256-0
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.21830 2.3% 2.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 5jna
no rotation
Molmil generated image of 5jna
rotated about x axis by 90°
Molmil generated image of 5jna
rotated about y axis by 90°