1T32

A Dual Inhibitor of the Leukocyte Proteases Cathepsin G and Chymase with Therapeutic Efficacy in Animals Models of Inflammation

Summary for 1T32

• Entry DOI: 10.2210/pdb1t32/pdb
• Related: 1CGH
• Descriptor: Cathepsin G, SULFATE ION, 2-[3-({METHYL[1-(2-NAPHTHOYL)PIPERIDIN-4-YL]AMINO}CARBONYL)-2-NAPHTHYL]-1-(1-NAPHTHYL)-2-OXOETHYLPHOSPHONIC ACID, ... (4 entities in total)
• Functional Keywords: inflammation inhibitor serine protease, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Cell surface: P08311
• Total number of polymer chains: 1
• Total formula weight: 26635.21

Authors

de Garavilla, L.,Greco, M.N.,Giardino, E.C.,Wells, G.I.,Haertlein, B.J.,Kauffman, J.A.,Corcoran, T.W.,Derian, C.K.,Eckardt, A.J.,Abraham, W.M.,Sukumar, N.,Chen, Z.,Pineda, A.O.,Mathews, F.S.,Di Cera, E.,Andrade-Gordon, P.,Damiano, B.P.,Maryanoff, B.E. (deposition date: 2004-04-23, release date: 2005-03-01, Last modification date: 2023-08-23)

• Primary citation: de Garavilla, L.,Greco, M.N.,Sukumar, N.,Chen, Z.W.,Pineda, A.O.,Mathews, F.S.,Di Cera, E.,Giardino, E.C.,Wells, G.I.,Haertlein, B.J.,Kauffman, J.A.,Corcoran, T.W.,Derian, C.K.,Eckardt, A.J.,Damiano, B.P.,Andrade-Gordon, P.,Maryanoff, B.E.; A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and anti-inflammatory activity in vivo.; J.Biol.Chem., 280:18001-18007, 2005; PubMed: 15741158; DOI: 10.1074/jbc.M501302200

Experimental method

X-RAY DIFFRACTION (1.85 Å)