6V64

Crystal structure of human thrombin bound to ppack with tryptophans replaced by 5-F-tryptophan

Summary for 6V64

• Entry DOI: 10.2210/pdb6v64/pdb
• Related: 1ppb
• Descriptor: Thrombin light chain, Thrombin heavy chain, SODIUM ION, ... (5 entities in total)
• Functional Keywords: hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 33960.07

Authors

Ruben, E.A.,Chen, Z.,Di Cera, E. (deposition date: 2019-12-04, release date: 2020-05-13, Last modification date: 2023-10-11)

• Primary citation: Ruben, E.A.,Gandhi, P.S.,Chen, Z.,Koester, S.K.,DeKoster, G.T.,Frieden, C.,Di Cera, E.; 19F NMR reveals the conformational properties of free thrombin and its zymogen precursor prethrombin-2.; J.Biol.Chem., 295:8227-8235, 2020; PubMed: 32358061; DOI: 10.1074/jbc.RA120.013419

Experimental method

X-RAY DIFFRACTION (2.29 Å)