1P4X
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![BU of 1p4x by Molmil](/molmil-images/mine/1p4x) | Crystal structure of SarS protein from Staphylococcus Aureus | Descriptor: | staphylococcal accessory regulator A homologue | Authors: | Li, R, Manna, A.C, Dai, S, Cheung, A.L, Zhang, G. | Deposit date: | 2003-04-24 | Release date: | 2003-07-08 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of the SarS protein from Staphylococcus aureus J.BACTERIOL., 185, 2003
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2W7X
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![BU of 2w7x by Molmil](/molmil-images/mine/2w7x) | Cellular inhibition of checkpoint kinase 2 and potentiation of cytotoxic drugs by novel Chk2 inhibitor PV1019 | Descriptor: | 1,2-ETHANEDIOL, MAGNESIUM ION, N-[4-[(E)-N-carbamimidamido-C-methyl-carbonimidoyl]phenyl]-7-nitro-1H-indole-2-carboxamide, ... | Authors: | Jobson, A.G, Lountos, G.T, Lorenzi, P.L, Llamas, J, Connelly, J, Tropea, J.E, Onda, A, Kondapaka, S, Zhang, G, Caplen, N.J, Caredellina, J.H, Monks, A, Self, C, Waugh, D.S, Shoemaker, R.H, Pommier, Y. | Deposit date: | 2009-01-06 | Release date: | 2009-09-22 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Cellular Inhibition of Chk2 Kinase and Potentiation of Camptothecins and Radiation by the Novel Chk2 Inhibitor Pv1019. J.Pharmacol.Exp.Ther., 331, 2009
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6MEV
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![BU of 6mev by Molmil](/molmil-images/mine/6mev) | Structure of JMJD6 bound to Mono-Methyl Arginine. | Descriptor: | (2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]pentanoic acid, 2-OXOGLUTARIC ACID, Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6, ... | Authors: | Lee, S, Zhang, G. | Deposit date: | 2018-09-07 | Release date: | 2019-09-18 | Last modified: | 2020-04-01 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | JMJD6 cleaves MePCE to release positive transcription elongation factor b (P-TEFb) in higher eukaryotes. Elife, 9, 2020
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5JFB
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![BU of 5jfb by Molmil](/molmil-images/mine/5jfb) | Crystal structure of the scavenger receptor cysteine-rich domain 5 (SRCR5) from porcine CD163 | Descriptor: | Scavenger receptor cysteine-rich type 1 protein M130 | Authors: | Ma, H, Jiang, L, Qiao, S, Zhang, G, Li, R. | Deposit date: | 2016-04-19 | Release date: | 2017-03-22 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The Crystal Structure of the Fifth Scavenger Receptor Cysteine-Rich Domain of Porcine CD163 Reveals an Important Residue Involved in Porcine Reproductive and Respiratory Syndrome Virus Infection J. Virol., 91, 2017
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6AVS
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![BU of 6avs by Molmil](/molmil-images/mine/6avs) | Complex structure of JMJD5 and Symmetric Monomethyl-Arginine (MMA) | Descriptor: | (2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]pentanoic acid, Lysine-specific demethylase 8, ZINC ION | Authors: | Lee, S, Liu, H, Wang, Y, Dai, S, Zhang, G. | Deposit date: | 2017-09-04 | Release date: | 2018-02-28 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Specific Recognition of Arginine Methylated Histone Tails by JMJD5 and JMJD7. Sci Rep, 8, 2018
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6AX3
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![BU of 6ax3 by Molmil](/molmil-images/mine/6ax3) | Complex structure of JMJD5 and Symmetric Dimethyl-Arginine (SDMA) | Descriptor: | 2-OXOGLUTARIC ACID, Lysine-specific demethylase 8, N3, ... | Authors: | Lee, S, Liu, H, Wang, Y, Dai, S, Zhang, G. | Deposit date: | 2017-09-06 | Release date: | 2018-02-28 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Specific Recognition of Arginine Methylated Histone Tails by JMJD5 and JMJD7. Sci Rep, 8, 2018
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4KEG
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![BU of 4keg by Molmil](/molmil-images/mine/4keg) | Crystal Structure of MBP Fused Human SPLUNC1 | Descriptor: | MAGNESIUM ION, Maltose-binding periplasmic/Palate lung and nasal epithelium clone fusion protein, octyl beta-D-glucopyranoside | Authors: | Ning, F, Wang, C, Niu, L, Chu, H.W, Zhang, G. | Deposit date: | 2013-04-25 | Release date: | 2014-04-30 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The Lipid Ligands of the SPLUNC1 Protein To be Published
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4N4X
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![BU of 4n4x by Molmil](/molmil-images/mine/4n4x) | Crystal Structure of the MBP fused human SPLUNC1 (native form) | Descriptor: | DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, Maltose-binding periplasmic/Palate lung and nasal epithelium clone fusion protein | Authors: | Ning, F, Wang, C, Niu, L, Chu, H.W, Zhang, G. | Deposit date: | 2013-10-08 | Release date: | 2014-09-17 | Last modified: | 2019-07-17 | Method: | X-RAY DIFFRACTION (2.501 Å) | Cite: | Lipid ligands of human SPLUNC1 To be Published
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2YCR
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![BU of 2ycr by Molmil](/molmil-images/mine/2ycr) | Crystal structure of checkpoint kinase 2 in complex with inhibitor PV976 | Descriptor: | 1,3-BIS{4-[(1E)-N-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)ETHANEHYDRAZONOYL]PHENYL}UREA, NITRATE ION, SERINE/THREONINE-PROTEIN KINASE CHK2 | Authors: | Lountos, G.T, Jobson, A.G, Tropea, J.E, Self, C.R, Pommier, Y, Shoemaker, R.H, Zhang, G, Waugh, D.S. | Deposit date: | 2011-03-16 | Release date: | 2011-11-16 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural Characterization of Inhibitor Complexes with Checkpoint Kinase 2 (Chk2), a Drug Target for Cancer Therapy. J.Struct.Biol., 176, 2011
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2YCS
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![BU of 2ycs by Molmil](/molmil-images/mine/2ycs) | Crystal structure of checkpoint kinase 2 in complex with PV788 | Descriptor: | N-{4-[(1E)-N-CARBAMIMIDOYLETHANEHYDRAZONOYL]PHENYL}-1H-INDOLE-3-CARBOXAMIDE, NITRATE ION, SERINE/THREONINE-PROTEIN KINASE CHK2 | Authors: | Lountos, G.T, Jobson, A.G, Tropea, J.E, Self, C.R, Pommier, Y, Shoemaker, R.H, Zhang, G, Waugh, D.S. | Deposit date: | 2011-03-16 | Release date: | 2011-11-16 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structural Characterization of Inhibitor Complexes with Checkpoint Kinase 2 (Chk2), a Drug Target for Cancer Therapy. J.Struct.Biol., 176, 2011
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2YCQ
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![BU of 2ycq by Molmil](/molmil-images/mine/2ycq) | Crystal structure of checkpoint kinase 2 in complex with inhibitor PV1115 | Descriptor: | N-{4-[(1E)-N-1H-IMIDAZOL-2-YLETHANEHYDRAZONOYL]PHENYL}-7-NITRO-1H-INDOLE-2-CARBOXAMIDE, NITRATE ION, SERINE/THREONINE-PROTEIN KINASE CHK2 | Authors: | Lountos, G.T, Jobson, A.G, Tropea, J.E, Self, C.R, Pommier, Y, Shoemaker, R.H, Zhang, G, Waugh, D.S. | Deposit date: | 2011-03-16 | Release date: | 2011-11-16 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structural Characterization of Inhibitor Complexes with Checkpoint Kinase 2 (Chk2), a Drug Target for Cancer Therapy. J.Struct.Biol., 176, 2011
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2YCF
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![BU of 2ycf by Molmil](/molmil-images/mine/2ycf) | Crystal Structure of Checkpoint Kinase 2 in complex with Inhibitor PV1531 | Descriptor: | (2E)-N-hydroxy-2-[1-(4-{[(4-{(1E)-1-[2-(N'-hydroxycarbamimidoyl)hydrazinylidene]ethyl}phenyl)carbamoyl]amino}phenyl)ethylidene]hydrazinecarboximidamide, MAGNESIUM ION, NITRATE ION, ... | Authors: | Lountos, G.T, Jobson, A.G, Tropea, J.E, Self, C.R, Pommier, Y, Shoemaker, R.H, Zhang, G, Waugh, D.S. | Deposit date: | 2011-03-14 | Release date: | 2011-11-16 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | Structural Characterization of Inhibitor Complexes with Checkpoint Kinase 2 (Chk2), a Drug Target for Cancer Therapy. J.Struct.Biol., 176, 2011
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6K0L
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![BU of 6k0l by Molmil](/molmil-images/mine/6k0l) | The crystal structure of simian CD163 SRCR5 | Descriptor: | Scavenger receptor cysteine-rich type 1 protein M130 | Authors: | Ma, H, Li, R, Jiang, L, Qiao, S, Zhang, G. | Deposit date: | 2019-05-07 | Release date: | 2020-05-13 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Structural comparison of CD163 SRCR5 from different species sheds some light on its involvement in porcine reproductive and respiratory syndrome virus-2 infection in vitro. Vet Res, 52, 2021
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6K0O
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![BU of 6k0o by Molmil](/molmil-images/mine/6k0o) | The crystal structure of human CD163-like homolog SRCR8 | Descriptor: | Scavenger receptor cysteine-rich type 1 protein M160 | Authors: | Ma, H, Li, R, Jiang, L, Qiao, S, Zhang, G. | Deposit date: | 2019-05-07 | Release date: | 2020-05-13 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Structural comparison of CD163 SRCR5 from different species sheds some light on its involvement in porcine reproductive and respiratory syndrome virus-2 infection in vitro. Vet Res, 52, 2021
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6LM2
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![BU of 6lm2 by Molmil](/molmil-images/mine/6lm2) | |
6LPS
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![BU of 6lps by Molmil](/molmil-images/mine/6lps) | |
2HFR
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![BU of 2hfr by Molmil](/molmil-images/mine/2hfr) | solution structure of antimicrobial peptide Fowlicidin 3 | Descriptor: | Fowlicidin-3 | Authors: | Bommineni, Y.R, Dai, H, Gong, Y, Prakash, O, Zhang, G. | Deposit date: | 2006-06-26 | Release date: | 2007-04-17 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Fowlicidin-3 is an alpha-helical cationic host defense peptide with potent antibacterial and lipopolysaccharide-neutralizing activities. Febs J., 274, 2007
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7W2I
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![BU of 7w2i by Molmil](/molmil-images/mine/7w2i) | Crystal structure of LOG (Rv1205) from Mycobacterium tuberculosis | Descriptor: | 1,2-ETHANEDIOL, Cytokinin riboside 5'-monophosphate phosphoribohydrolase, DI(HYDROXYETHYL)ETHER, ... | Authors: | Shang, L, Zhang, G. | Deposit date: | 2021-11-23 | Release date: | 2022-07-06 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of the cytokinin-producing enzyme "lonely guy" (LOG) from Mycobacterium tuberculosis. Biochem.Biophys.Res.Commun., 598, 2022
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8F5Q
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![BU of 8f5q by Molmil](/molmil-images/mine/8f5q) | Crystal structure of human PCNA in complex with the PIP box of FBH1 | Descriptor: | F-box DNA helicase 1, Proliferating cell nuclear antigen | Authors: | Liu, J, Chaves-Arquero, B, Wei, P, Tencer, H, Zhang, G, Blanco, F, Kutateladze, T. | Deposit date: | 2022-11-15 | Release date: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Molecular insight into the PCNA-binding mode of FBH1. Structure, 31, 2023
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7CJF
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![BU of 7cjf by Molmil](/molmil-images/mine/7cjf) | Crystal structure of SARS-CoV-2 RBD in complex with a neutralizing antibody Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, antibody heavy chain, ... | Authors: | Guo, Y, Li, X, Zhang, G, Fu, D, Schweizer, L, Zhang, H, Rao, Z. | Deposit date: | 2020-07-10 | Release date: | 2020-11-11 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.108 Å) | Cite: | A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes. Nat Commun, 12, 2021
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2LQV
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![BU of 2lqv by Molmil](/molmil-images/mine/2lqv) | YebF | Descriptor: | Protein yebF | Authors: | Prehna, G, Zhang, G, Gong, X, Duszyk, M, Okon, M, Mcintosh, L.P, Weiner, J.H, Strynadka, N.C.J. | Deposit date: | 2012-03-16 | Release date: | 2012-06-13 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | A Protein Export Pathway Involving Escherichia coli Porins. Structure, 20, 2012
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3DXT
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![BU of 3dxt by Molmil](/molmil-images/mine/3dxt) | |
3DXU
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![BU of 3dxu by Molmil](/molmil-images/mine/3dxu) | |
8GOU
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![BU of 8gou by Molmil](/molmil-images/mine/8gou) | Omicron BA.4/5 SARS-CoV-2 S in complex with TH003 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, TH003 Fab heavy chain, ... | Authors: | Guo, Y, Zhang, G, Liang, J, Liu, F, Rao, Z. | Deposit date: | 2022-08-25 | Release date: | 2023-06-28 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection. Nat Commun, 14, 2023
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8IL3
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![BU of 8il3 by Molmil](/molmil-images/mine/8il3) | Cryo-EM structure of CD38 in complex with FTL004 | Descriptor: | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, Heavy chain, Light chain | Authors: | Yang, J, Wang, Y, Zhang, G. | Deposit date: | 2023-03-01 | Release date: | 2023-03-29 | Method: | ELECTRON MICROSCOPY (3.86 Å) | Cite: | FTL004, an anti-CD38 mAb with negligible RBC binding and enhanced pro-apoptotic activity, is a novel candidate for treatments of multiple myeloma and non-Hodgkin lymphoma. J Hematol Oncol, 15, 2022
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