8IL3

Cryo-EM structure of CD38 in complex with FTL004

Summary for 8IL3

• Entry DOI: 10.2210/pdb8il3/pdb
• EMDB information: 35526
• Descriptor: Light chain, Heavy chain, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (3 entities in total)
• Functional Keywords: monoclonal antibody, hydrolase
• Biological source: Homo sapiens; More
• Total number of polymer chains: 3
• Total formula weight: 73581.55

Authors

Yang, J.,Wang, Y.,Zhang, G. (deposition date: 2023-03-01, release date: 2023-03-29)

• Primary citation: Zhang, G.,Guo, C.,Wang, Y.,Zhang, X.,Liu, S.,Qu, W.,Chen, C.,Yan, L.,Yang, Z.,Zhang, Z.,Jiang, X.,Chen, X.,Liu, H.,Lai, Q.,Wei, X.,Lu, Y.,Zhao, S.,Deng, H.,Wang, Y.,Yu, L.,Yu, H.,Wu, Y.,Su, Z.,Chen, P.,Ren, Z.,Yu, M.,Qu, F.,Luo, Y.,Gou, L.,Li, Q.,Huang, Y.,Ma, F.,Yang, J.; FTL004, an anti-CD38 mAb with negligible RBC binding and enhanced pro-apoptotic activity, is a novel candidate for treatments of multiple myeloma and non-Hodgkin lymphoma.; J Hematol Oncol, 15:177-177, 2022; PubMed: 36581954; DOI: 10.1186/s13045-022-01395-0

Experimental method

ELECTRON MICROSCOPY (3.86 Å)