Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

2YCF

Crystal Structure of Checkpoint Kinase 2 in complex with Inhibitor PV1531

Summary for 2YCF
Entry DOI10.2210/pdb2ycf/pdb
Related1GXC 2CN5 2CN8 2W0J 2W7X 2WTC 2WTD 2WTI 2WTJ 2XBJ 2XM8 2XM9
DescriptorSERINE/THREONINE-PROTEIN KINASE CHK2, (2E)-N-hydroxy-2-[1-(4-{[(4-{(1E)-1-[2-(N'-hydroxycarbamimidoyl)hydrazinylidene]ethyl}phenyl)carbamoyl]amino}phenyl)ethylidene]hydrazinecarboximidamide, MAGNESIUM ION, ... (5 entities in total)
Functional Keywordstransferase, anticancer, anticancer drug design
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationIsoform 2: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 9: Nucleus. Isoform 12: Nucleus. Nucleus, PML body: O96017
Total number of polymer chains1
Total formula weight36959.89
Authors
Lountos, G.T.,Jobson, A.G.,Tropea, J.E.,Self, C.R.,Pommier, Y.,Shoemaker, R.H.,Zhang, G.,Waugh, D.S. (deposition date: 2011-03-14, release date: 2011-11-16, Last modification date: 2023-12-20)
Primary citationLountos, G.T.,Jobson, A.G.,Tropea, J.E.,Self, C.R.,Zhang, G.,Pommier, Y.,Shoemaker, R.H.,Waugh, D.S.
Structural Characterization of Inhibitor Complexes with Checkpoint Kinase 2 (Chk2), a Drug Target for Cancer Therapy.
J.Struct.Biol., 176:292-, 2011
Cited by
PubMed: 21963792
DOI: 10.1016/J.JSB.2011.09.008
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.77 Å)
Structure validation

217157

PDB entries from 2024-03-13

PDB statisticsPDBj update infoContact PDBjnumon