2CN8

Crystal structure of human Chk2 in complex with debromohymenialdisine

Summary for 2CN8

Entry DOI	10.2210/pdb2cn8/pdb
Related	1GXC 2CN5
Descriptor	SERINE/THREONINE-PROTEIN KINASE CHK2, MAGNESIUM ION, NITRATE ION, ... (5 entities in total)
Functional Keywords	atp-binding, transferase, kinase domain, phosphorylation, tumour suppressor, activation segment, li-fraumeni syndrome, serine/threonine-protein kinase, chk2, cds1, rad53, chek2, kinase, cancer, checkpoint, nucleotide-binding, hypothetical protein
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Isoform 2: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 9: Nucleus. Isoform 12: Nucleus. Nucleus, PML body: O96017
Total number of polymer chains	1
Total formula weight	37443.39
Authors	Oliver, A.W.,Pearl, L.H. (deposition date: 2006-05-18, release date: 2006-06-28, Last modification date: 2023-12-13)
Primary citation	Oliver, A.W.,Paul, A.,Boxall, K.J.,Barrie, S.E.,Aherne, G.W.,Garrett, M.D.,Mittnacht, S.,Pearl, L.H. Trans-Activation of the DNA-Damage Signalling Protein Kinase Chk2 by T-Loop Exchange Embo J., 25:3179-, 2006 Cited by PubMed: 16794575 DOI: 10.1038/SJ.EMBOJ.7601209 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation