2WTI
CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH AN INHIBITOR
Summary for 2WTI
Entry DOI | 10.2210/pdb2wti/pdb |
Related | 2WTC 2WTD 2WTJ |
Descriptor | CHECKPOINT KINASE 2, 4-[2-AMINO-5-(2,3-DIHYDROTHIENO[3,4-B][1,4]DIOXIN-5-YL)PYRIDIN-3-YL]BENZAMIDE, NITRATE ION, ... (5 entities in total) |
Functional Keywords | transferase, kinase, cell cycle, li-fraumeni syndrome |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 37713.38 |
Authors | Hilton, S.,Naud, S.,Caldwell, J.J.,Boxall, K.,Burns, S.,Anderson, V.E.,Antoni, L.,Allen, C.E.,Pearl, L.H.,Oliver, A.W.,Aherne, G.W.,Garrett, M.D.,Collins, I. (deposition date: 2009-09-16, release date: 2009-12-29, Last modification date: 2023-12-20) |
Primary citation | Hilton, S.,Naud, S.,Caldwell, J.J.,Boxall, K.,Burns, S.,Anderson, V.E.,Antoni, L.,Allen, C.E.,Pearl, L.H.,Oliver, A.W.,Aherne, G.W.,Garrett, M.D.,Collins, I. Identification and Characterisation of 2-Aminopyridine Inhibitors of Checkpoint Kinase 2 Bioorg.Med.Chem., 18:707-, 2010 Cited by PubMed: 20022510DOI: 10.1016/J.BMC.2009.11.058 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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