2WTD
Crystal structure of Chk2 in complex with an inhibitor
Summary for 2WTD
Entry DOI | 10.2210/pdb2wtd/pdb |
Related | 1GXC 2CN5 2CN8 2W0J 2W7X 2WTC 2WTI 2WTJ |
Descriptor | SERINE/THREONINE-PROTEIN KINASE CHK2, 4-[2-AMINO-5-(1,3-BENZODIOXOL-4-YL)PYRIDIN-3-YL]BENZAMIDE, NITRATE ION, ... (5 entities in total) |
Functional Keywords | transferase, kinase, cell cycle, li-fraumeni syndrome |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Isoform 2: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 9: Nucleus. Isoform 12: Nucleus. Nucleus, PML body: O96017 |
Total number of polymer chains | 1 |
Total formula weight | 37693.39 |
Authors | Hilton, S.,Naud, S.,Caldwell, J.J.,Boxall, K.,Burns, S.,Anderson, V.E.,Antoni, L.,Allen, C.E.,Pearl, L.H.,Oliver, A.W.,Aherne, G.W.,Garrett, M.D.,Collins, I. (deposition date: 2009-09-15, release date: 2009-12-29, Last modification date: 2023-12-20) |
Primary citation | Hilton, S.,Naud, S.,Caldwell, J.J.,Boxall, K.,Burns, S.,Anderson, V.E.,Antoni, L.,Allen, C.E.,Pearl, L.H.,Oliver, A.W.,Aherne, G.W.,Garrett, M.D.,Collins, I. Identification and Characterisation of 2-Aminopyridine Inhibitors of Checkpoint Kinase 2 Bioorg.Med.Chem., 18:707-, 2010 Cited by PubMed: 20022510DOI: 10.1016/J.BMC.2009.11.058 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.75 Å) |
Structure validation
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