2WTJ

CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH AN INHIBITOR

Summary for 2WTJ

Entry DOI	10.2210/pdb2wtj/pdb
Related	2WTC 2WTD 2WTI
Descriptor	CHECKPOINT KINASE 2, 2-AMINO-5-(2,3-DIHYDROTHIENO[3,4-B][1,4]DIOXIN-5-YL)-N-[2-(DIMETHYLAMINO)ETHYL]PYRIDINE-3-CARBOXAMIDE, NITRATE ION, ... (5 entities in total)
Functional Keywords	transferase, kinase, cell cycle, li-fraumeni syndrome
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	37832.55
Authors	Hilton, S.,Naud, S.,Caldwell, J.J.,Boxall, K.,Burns, S.,Anderson, V.E.,Antoni, L.,Allen, C.E.,Pearl, L.H.,Oliver, A.W.,Aherne, G.W.,Garrett, M.D.,Collins, I. (deposition date: 2009-09-16, release date: 2009-12-29, Last modification date: 2023-12-20)
Primary citation	Hilton, S.,Naud, S.,Caldwell, J.J.,Boxall, K.,Burns, S.,Anderson, V.E.,Antoni, L.,Allen, C.E.,Pearl, L.H.,Oliver, A.W.,Aherne, G.W.,Garrett, M.D.,Collins, I. Identification and Characterisation of 2-Aminopyridine Inhibitors of Checkpoint Kinase 2 Bioorg.Med.Chem., 18:707-, 2010 Cited by PubMed: 20022510 DOI: 10.1016/J.BMC.2009.11.058 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation