7U18

TMEM106B(120-254) T185S protofilament from frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) type A (all cases combined).

Summary for 7U18

• Entry DOI: 10.2210/pdb7u18/pdb
• EMDB information: 26279
• Descriptor: TMEM106B protein, 2-acetamido-2-deoxy-beta-D-glucopyranose (2 entities in total)
• Functional Keywords: tmem106b, amyloid fibril, unknown function
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 3
• Total formula weight: 49120.45

Authors

Fitzpatrick, A.W.P.,Stowell, M.H.B.,Chang, A.,Xiang, X.,Wang, J.,Lee, C.,Arakhamia, T.,Simjanoska, M.,Wang, C.,Carlomagno, Y.,Zhang, G.,Dhingra, S.,Thierry, M.,Perneel, J.,Heeman, B.,Forgrave, L.M.,DeTure, M.,DeMarco, M.L.,Cook, C.N.,Rademakers, R.,Dickson, D.,Petrucelli, L.,Mackenzie, I.R.A. (deposition date: 2022-02-20, release date: 2022-03-23, Last modification date: 2022-04-27)

• Primary citation: Chang, A.,Xiang, X.,Wang, J.,Lee, C.,Arakhamia, T.,Simjanoska, M.,Wang, C.,Carlomagno, Y.,Zhang, G.,Dhingra, S.,Thierry, M.,Perneel, J.,Heeman, B.,Forgrave, L.M.,DeTure, M.,DeMarco, M.L.,Cook, C.N.,Rademakers, R.,Dickson, D.W.,Petrucelli, L.,Stowell, M.H.B.,Mackenzie, I.R.A.,Fitzpatrick, A.W.P.; Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases.; Cell, 185:1346-1355.e15, 2022; PubMed: 35247328; DOI: 10.1016/j.cell.2022.02.026

Experimental method

ELECTRON MICROSCOPY (2.7 Å)