7U10

TMEM106B(120-254) protofilament from progressive supranuclear palsy (PSP) case 2

Summary for 7U10

Entry DOI	10.2210/pdb7u10/pdb
EMDB information	26268 26273 26274 26275 26276
Descriptor	Transmembrane protein 106B, 2-acetamido-2-deoxy-beta-D-glucopyranose (2 entities in total)
Functional Keywords	tmem106b, amyloid fibril, protein fibril
Biological source	Homo sapiens (human)
Total number of polymer chains	3
Total formula weight	49162.54
Authors	Fitzpatrick, A.W.P.,Stowell, M.H.B.,Chang, A.,Xiang, X.,Wang, J.,Lee, C.,Arakhamia, T.,Simjanoska, M.,Wang, C.,Carlomagno, Y.,Zhang, G.,Dhingra, S.,Thierry, M.,Perneel, J.,Heeman, B.,Forgrave, L.M.,DeTure, M.,DeMarco, M.L.,Cook, C.N.,Rademakers, R.,Dickson, D.,Petrucelli, L.,Mackenzie, I.R.A. (deposition date: 2022-02-19, release date: 2022-03-23, Last modification date: 2022-04-27)
Primary citation	Chang, A.,Xiang, X.,Wang, J.,Lee, C.,Arakhamia, T.,Simjanoska, M.,Wang, C.,Carlomagno, Y.,Zhang, G.,Dhingra, S.,Thierry, M.,Perneel, J.,Heeman, B.,Forgrave, L.M.,DeTure, M.,DeMarco, M.L.,Cook, C.N.,Rademakers, R.,Dickson, D.W.,Petrucelli, L.,Stowell, M.H.B.,Mackenzie, I.R.A.,Fitzpatrick, A.W.P. Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases. Cell, 185:1346-1355.e15, 2022 Cited by PubMed: 35247328 DOI: 10.1016/j.cell.2022.02.026 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3 Å)

Structure validation