7U11
TMEM106B(120-254) protofilament from frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) type A (case 1)
Summary for 7U11
Entry DOI | 10.2210/pdb7u11/pdb |
EMDB information | 26268 26273 26274 26275 26276 |
Descriptor | Transmembrane protein 106B, 2-acetamido-2-deoxy-beta-D-glucopyranose (2 entities in total) |
Functional Keywords | tmem106b, amyloid fibril, protein fibril |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 3 |
Total formula weight | 49162.54 |
Authors | Fitzpatrick, A.W.P.,Stowell, M.H.B.,Chang, A.,Xiang, X.,Wang, J.,Lee, C.,Arakhamia, T.,Simjanoska, M.,Wang, C.,Carlomagno, Y.,Zhang, G.,Dhingra, S.,Thierry, M.,Perneel, J.,Heeman, B.,Forgrave, L.M.,DeTure, M.,DeMarco, M.L.,Cook, C.N.,Rademakers, R.,Dickson, D.,Petrucelli, L.,Mackenzie, I.R.A. (deposition date: 2022-02-19, release date: 2022-03-23, Last modification date: 2022-04-27) |
Primary citation | Chang, A.,Xiang, X.,Wang, J.,Lee, C.,Arakhamia, T.,Simjanoska, M.,Wang, C.,Carlomagno, Y.,Zhang, G.,Dhingra, S.,Thierry, M.,Perneel, J.,Heeman, B.,Forgrave, L.M.,DeTure, M.,DeMarco, M.L.,Cook, C.N.,Rademakers, R.,Dickson, D.W.,Petrucelli, L.,Stowell, M.H.B.,Mackenzie, I.R.A.,Fitzpatrick, A.W.P. Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases. Cell, 185:1346-1355.e15, 2022 Cited by PubMed: 35247328DOI: 10.1016/j.cell.2022.02.026 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.2 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)