4YHC
 
 | | Crystal structure of the WD40 domain of SCAP from fission yeast | | Descriptor: | CITRIC ACID, Sterol regulatory element-binding protein cleavage-activating protein | | Authors: | Gong, X, Li, J.X, Wu, J.P, Yan, C.Y, Yan, N. | | Deposit date: | 2015-02-27 | | Release date: | 2015-04-01 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Structure of the WD40 domain of SCAP from fission yeast reveals the molecular basis for SREBP recognition.
Cell Res., 25, 2015
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4TTP
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5JNX
 | | The 6.6 A cryo-EM structure of the full-length human NPC1 in complex with the cleaved glycoprotein of Ebola virus | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein, ... | | Authors: | Gong, X, Qian, H.W, Zhou, X.H, Wu, J.P, Wan, T, Shi, Y, Gao, F, Zhou, Q, Yan, N. | | Deposit date: | 2016-05-01 | | Release date: | 2016-06-15 | | Last modified: | 2020-08-05 | | Method: | ELECTRON MICROSCOPY (6.56 Å) | | Cite: | Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection
Cell, 165, 2016
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7F69
 | | Crystal structure of WIPI2b in complex with ATG16L1 | | Descriptor: | Isoform 2 of Autophagy-related protein 16-1, Isoform 2 of WD repeat domain phosphoinositide-interacting protein 2 | | Authors: | Gong, X.Y, Pan, L.F. | | Deposit date: | 2021-06-24 | | Release date: | 2022-07-27 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | ATG16L1 adopts a dual-binding site mode to interact with WIPI2b in autophagy.
Sci Adv, 9, 2023
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3JD8
 | | cryo-EM structure of the full-length human NPC1 at 4.4 angstrom | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | | Authors: | Gong, X, Qian, H.W, Zhou, X.H, Wu, J.P, Zhou, Q, Yan, N. | | Deposit date: | 2016-05-01 | | Release date: | 2016-06-01 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (4.43 Å) | | Cite: | The structure of Niemann-Pick C1 protein
To Be Published
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5GPD
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8I2N
 | | The RIPK1 kinase domain in complex with QY7-2B compound | | Descriptor: | Receptor-interacting serine/threonine-protein kinase 1, ~{N}-methyl-1-[4-[[[1-methyl-5-(phenylmethyl)pyrazol-3-yl]carbonylamino]methyl]phenyl]benzimidazole-5-carboxamide | | Authors: | Gong, X.Y, Li, Y, Meng, H.Y, Pan, L.F. | | Deposit date: | 2023-01-14 | | Release date: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.29 Å) | | Cite: | The RIPK1 kinase domain in complex with QY7-2B compound
To Be Published
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5GRS
 | | Complex structure of the fission yeast SREBP-SCAP binding domains | | Descriptor: | Sterol regulatory element-binding protein 1, Sterol regulatory element-binding protein cleavage-activating protein | | Authors: | Gong, X, Qian, H.W, Wu, J.P, Yan, N. | | Deposit date: | 2016-08-12 | | Release date: | 2016-12-14 | | Last modified: | 2019-10-23 | | Method: | ELECTRON MICROSCOPY (5.4 Å) | | Cite: | Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization
Cell Res., 26, 2016
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7XFR
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6A0Q
 | | The crystal structure of Lpg2622_E64 complex | | Descriptor: | Lpg2622, N-[N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-BUTYL]-GUANIDINE | | Authors: | Gong, X, Ge, H. | | Deposit date: | 2018-06-06 | | Release date: | 2018-09-12 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural characterization of the hypothetical protein Lpg2622, a new member of the C1 family peptidases from Legionella pneumophila
FEBS Lett., 592, 2018
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6A0N
 | | The crystal structure of apo-Lpg2622 | | Descriptor: | Lpg2622 | | Authors: | Gong, X, Ge, H. | | Deposit date: | 2018-06-05 | | Release date: | 2018-09-12 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural characterization of the hypothetical protein Lpg2622, a new member of the C1 family peptidases from Legionella pneumophila
FEBS Lett., 592, 2018
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5ZFM
 | | Ketoreductase LbCR mutant - M6 | | Descriptor: | 3-oxoacyl-acyl carrier protein reductase | | Authors: | Gong, X.M, Zheng, G.W, Xu, J.H. | | Deposit date: | 2018-03-06 | | Release date: | 2019-01-16 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Development of an Engineered Ketoreductase with Simultaneously Improved Thermostability and Activity for Making a Bulky Atorvastatin Precursor
Acs Catalysis, 9, 2019
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5ZI0
 | | Ketoreductase LbCR mutant - M8 | | Descriptor: | 3-oxoacyl-acyl carrier protein reductase | | Authors: | Gong, X.M, Zheng, G.W, Xu, J.H. | | Deposit date: | 2018-03-14 | | Release date: | 2019-01-16 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.302 Å) | | Cite: | Development of an Engineered Ketoreductase with Simultaneously Improved Thermostability and Activity for Making a Bulky Atorvastatin Precursor
Acs Catalysis, 9, 2019
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6DMB
 | | Cryo-EM structure of human Ptch1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ... | | Authors: | Yan, N, Gong, X, Qian, H.W. | | Deposit date: | 2018-06-04 | | Release date: | 2018-07-11 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structural basis for the recognition of Sonic Hedgehog by human Patched1.
Science, 361, 2018
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6DMY
 | | Cryo-EM structure of human Ptch1 and ShhN complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Yan, N, Gong, X, Qian, H.W. | | Deposit date: | 2018-06-05 | | Release date: | 2018-07-11 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structural basis for the recognition of Sonic Hedgehog by human Patched1.
Science, 361, 2018
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6DMO
 | | Cryo-EM structure of human Ptch1 with three mutations L282Q/T500F/P504L | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Protein patched homolog 1 | | Authors: | Yan, N, Gong, X, Qian, H.W. | | Deposit date: | 2018-06-05 | | Release date: | 2018-07-11 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Structural basis for the recognition of Sonic Hedgehog by human Patched1.
Science, 361, 2018
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5H6X
 | | The crystal structure of RpoS fragment including a partial region 1.2 and region 2 from intracellular pathogen Legionella pneumophila | | Descriptor: | GLYCEROL, RNA polymerase sigma factor RpoS, SODIUM ION | | Authors: | Zhang, N, Chen, X, Gong, X, Ge, H. | | Deposit date: | 2016-11-15 | | Release date: | 2017-11-22 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | High-Resolution Crystal Structure of RpoS Fragment including a Partial Region 1.2 and Region 2 from the Intracellular Pathogen Legionella pneumophila
Crystals, 8, 2018
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8IAM
 | | Cryo-EM structure of the yeast SPT-ORM2 (ORM2-S3D) complex | | Descriptor: | Chimera of Long chain base biosynthesis protein 1 and Serine palmitoyltransferase 1, N-[(2S,3R,4E)-1,3-dihydroxyoctadec-4-en-2-yl]tetracosanamide, PYRIDOXAL-5'-PHOSPHATE, ... | | Authors: | Xie, T, Gong, X. | | Deposit date: | 2023-02-08 | | Release date: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Collaborative regulation of yeast SPT-Orm2 complex by phosphorylation and ceramide.
Cell Rep, 43, 2024
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8IAK
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8IAJ
 | | Cryo-EM structure of the yeast SPT-ORM2 (ORM2-S3A) complex | | Descriptor: | N-[(2S,3R,4E)-1,3-dihydroxyoctadec-4-en-2-yl]tetracosanamide, PYRIDOXAL-5'-PHOSPHATE, Protein ORM2, ... | | Authors: | Xie, T, Gong, X. | | Deposit date: | 2023-02-08 | | Release date: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Collaborative regulation of yeast SPT-Orm2 complex by phosphorylation and ceramide.
Cell Rep, 43, 2024
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5GYY
 | | Plant receptor complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, S-locus protein 11, S-receptor kinase SRK9 | | Authors: | Ma, R, Han, Z, Hu, Z, Lin, G, Gong, X, Zhang, H, June, N, Chai, J. | | Deposit date: | 2016-09-24 | | Release date: | 2017-09-27 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.351 Å) | | Cite: | Plant receptor complex at 2.35 Angstroms resolution
To Be Published
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2MKV
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8IZD
 | | Cryo-EM structure of the C26-CoA-bound Lac1-Lip1 complex | | Descriptor: | (4S,7R)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE, Ceramide synthase LAC1, Ceramide synthase subunit LIP1, ... | | Authors: | Xie, T, Fang, Q, Gong, X. | | Deposit date: | 2023-04-07 | | Release date: | 2023-12-13 | | Last modified: | 2023-12-20 | | Method: | ELECTRON MICROSCOPY (3.09 Å) | | Cite: | Structure and mechanism of a eukaryotic ceramide synthase complex.
Embo J., 42, 2023
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8IZF
 | | Cryo-EM structure of the Lac1-Lip1 (Lip1-S74F) complex | | Descriptor: | (4S,7R)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE, Ceramide synthase LAC1, Ceramide synthase subunit LIP1 | | Authors: | Xie, T, Fang, Q, Gong, X. | | Deposit date: | 2023-04-07 | | Release date: | 2023-12-13 | | Last modified: | 2023-12-20 | | Method: | ELECTRON MICROSCOPY (3.85 Å) | | Cite: | Structure and mechanism of a eukaryotic ceramide synthase complex.
Embo J., 42, 2023
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7W02
 | | Cryo-EM structure of ATP-bound ABCA3 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Xie, T, Zhang, Z.K, Yue, J, Gong, X. | | Deposit date: | 2021-11-17 | | Release date: | 2022-04-20 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Cryo-EM structures of the human surfactant lipid transporter ABCA3.
Sci Adv, 8, 2022
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