Ketoreductase LbCR mutant - M6

Summary for 5ZFM

Descriptor3-oxoacyl-acyl carrier protein reductase (2 entities in total)
Functional Keywordsketoreductase, short-chain dehydrogenase/reductase (sdr), oxidoreductase
Biological sourceLactobacillus brevis (strain ATCC 367 / JCM 1170)
Total number of polymer chains4
Total molecular weight118213.82
Gong, X.M.,Zheng, G.W.,Xu, J.H. (deposition date: 2018-03-06, release date: 2019-01-16)
Primary citation
Gong, X.M.,Zhen, Q.,Li, F.L.,Zeng, B.B.,Zheng, G.W.,Xu, J.H.
Development of an Engineered Ketoreductase with Simultaneously Improved Thermostability and Activity for Making a Bulky Atorvastatin Precursor
Acs Catalysis, 9:147-153, 2019
DOI: 10.1021/acscatal.8b03382
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.1953 0.2% 1.3% 2.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 5zfm
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Molmil generated image of 5zfm
rotated about x axis by 90°
Molmil generated image of 5zfm
rotated about y axis by 90°
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