8JDZ
 
 | | Crystal structure of mLDHD in complex with 2-keto-3-methylvaleric acid | | Descriptor: | (3S)-3-methyl-2-oxopentanoic acid, FLAVIN-ADENINE DINUCLEOTIDE, MANGANESE (II) ION, ... | | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | | Deposit date: | 2023-05-15 | | Release date: | 2023-10-18 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.56 Å) | | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Nat Commun, 14, 2023
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8JDS
 | | Crystal structure of mLDHD in complex with Pyruvate | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, MANGANESE (II) ION, PYRUVIC ACID, ... | | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | | Deposit date: | 2023-05-15 | | Release date: | 2023-10-18 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.636 Å) | | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Nat Commun, 14, 2023
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8JDE
 | | Crystal structure of mLDHD in complex with D-lactate | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, LACTIC ACID, MANGANESE (II) ION, ... | | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | | Deposit date: | 2023-05-13 | | Release date: | 2023-10-18 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.729 Å) | | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Nat Commun, 14, 2023
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8JDV
 | | Crystal structure of mLDHD in complex with 2-ketohexanoic acid | | Descriptor: | 2-Ketohexanoic acid, FLAVIN-ADENINE DINUCLEOTIDE, MANGANESE (II) ION, ... | | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | | Deposit date: | 2023-05-15 | | Release date: | 2023-10-18 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.96 Å) | | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Nat Commun, 14, 2023
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8JDY
 | | Crystal structure of mLDHD in complex with 2-ketoisocaproic acid | | Descriptor: | 2-OXO-4-METHYLPENTANOIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, MANGANESE (II) ION, ... | | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | | Deposit date: | 2023-05-15 | | Release date: | 2023-10-18 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.59 Å) | | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Nat Commun, 14, 2023
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8JDP
 | | Crystal structure of H405A mLDHD in complex with D-2-hydroxyisovaleric acid | | Descriptor: | DEAMINOHYDROXYVALINE, FLAVIN-ADENINE DINUCLEOTIDE, Probable D-lactate dehydrogenase, ... | | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | | Deposit date: | 2023-05-15 | | Release date: | 2023-10-18 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Nat Commun, 14, 2023
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8JDR
 | | Crystal structure of H405A mLDHD in complex with D-2-hydroxy-3-methyl-valeric acid | | Descriptor: | (2R,3S)-3-methyl-2-oxidanyl-pentanoic acid, FLAVIN-ADENINE DINUCLEOTIDE, Probable D-lactate dehydrogenase, ... | | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | | Deposit date: | 2023-05-15 | | Release date: | 2023-10-18 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.64 Å) | | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Nat Commun, 14, 2023
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8H1D
 | | Solid-state NMR Structure of Aquaporin Z in its Native Cellular Membranes | | Descriptor: | Aquaporin Z | | Authors: | Xie, H, Zhao, Y, Zhao, W, Chen, Y, Liu, M, Yang, J. | | Deposit date: | 2022-10-02 | | Release date: | 2022-11-09 | | Last modified: | 2024-05-15 | | Method: | SOLID-STATE NMR | | Cite: | Solid-state NMR structure determination of a membrane protein in E. coli cellular inner membrane.
Sci Adv, 9, 2023
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8J4I
 | | Unveiling the Role of Human Prohibitin 2 as a Mitochondrial Calcium Channel in Parkinson's Disease | | Descriptor: | Prohibitin-2 | | Authors: | Li, Y.Y, Fang, Y, Gao, Y.X, Ding, W, Yang, J, Liu, Y, Shen, B, Wang, J.F, Zhou, S. | | Deposit date: | 2023-04-20 | | Release date: | 2024-06-05 | | Method: | SOLUTION NMR | | Cite: | Human Prohibitin 2 is a Mitochondrial Ca2+-Selective Channel
To Be Published
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2MY1
 | | Solution structure of Bud31p | | Descriptor: | Pre-mRNA-splicing factor BUD31, ZINC ION | | Authors: | van Roon, A.M, Yang, J, Mathieu, D, Bermel, W, Nagai, K, Neuhaus, D. | | Deposit date: | 2015-01-19 | | Release date: | 2015-03-11 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | (113) Cd NMR Experiments Reveal an Unusual Metal Cluster in the Solution Structure of the Yeast Splicing Protein Bud31p.
Angew.Chem.Int.Ed.Engl., 54, 2015
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2O4X
 | | Crystal structure of human P100 tudor domain | | Descriptor: | Staphylococcal nuclease domain-containing protein 1 | | Authors: | Shaw, N, Zhao, M, Cheng, C, Xu, H, Yang, J, Silvennoinen, O, Rao, Z, Wang, B.C, Liu, Z.J. | | Deposit date: | 2006-12-05 | | Release date: | 2007-02-13 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of human P100 tudor domain
To be Published
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4M6R
 | | Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme | | Descriptor: | Methylthioribulose-1-phosphate dehydratase, ZINC ION | | Authors: | Kang, W, Hong, S.H, Lee, H.M, Kim, N.Y, Lim, Y.C, Le, L.T.M, Lim, B, Kim, H.C, Kim, T.Y, Ashida, H, Yokota, A, Hah, S.S, Chun, K.H, Jung, Y.K, Yang, J.K. | | Deposit date: | 2013-08-10 | | Release date: | 2014-01-29 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme.
Proc.Natl.Acad.Sci.USA, 111, 2014
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5XHC
 | | Crystal structure of T2R-TTL-PO10 complex | | Descriptor: | (3Z,6Z)-3-[(4-tert-butyl-1H-imidazol-5-yl)methylidene]-6-[[3-(4-fluorophenyl)carbonylphenyl]methylidene]piperazine-2,5-dione, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | | Authors: | Chu, Y, Wang, Y, Yang, J, Li, W. | | Deposit date: | 2017-04-20 | | Release date: | 2017-10-18 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Synthesis, biological evaluation and X-ray structure of anti-microtubule agents
To Be Published
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5XKG
 | | Crystal structure of T2R-TTL-CH1 complex | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-[(3-azanyl-4-methoxy-phenyl)-methyl-amino]chromen-2-one, CALCIUM ION, ... | | Authors: | Wang, Y, Yang, J, Wang, T, Chen, L. | | Deposit date: | 2017-05-07 | | Release date: | 2018-04-18 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Identification of a powerful and reversible microtubule-inhibitor with efficacy against multidrug-resistant tumors
To Be Published
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5XI5
 | | Crystal structure of T2R-TTL-PO5 complex | | Descriptor: | (3Z,6Z)-3-benzylidene-6-[(5-tert-butyl-1H-imidazol-4-yl)methylidene]piperazine-2,5-dione, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | | Authors: | Chu, Y, Wang, Y, Yang, J, Li, W. | | Deposit date: | 2017-04-26 | | Release date: | 2017-10-18 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.81 Å) | | Cite: | Synthesis, biological evaluation and X-ray structure of anti-microtubule agents
To Be Published
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5XKH
 | | Crystal structure of T2R-TTL-CF1 complex | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-[(4-methoxy-3-oxidanyl-phenyl)-methyl-amino]chromen-2-one, CALCIUM ION, ... | | Authors: | Wang, Y, Yang, J, Wang, T, Chen, L. | | Deposit date: | 2017-05-07 | | Release date: | 2018-06-20 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Identification of a powerful and reversible microtubule-inhibitor with efficacy against multidrug-resistant tumors
To Be Published
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5Z4U
 | | Crystal Structure of T2R-TTL complex with 7a3 | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-(4-ethoxyphenyl)-1-methyl-3-(3,4,5-trimethoxyphenyl)-1H-pyrazole, CALCIUM ION, ... | | Authors: | Lai, Q, Wang, Y, Yang, J, Yao, Y. | | Deposit date: | 2018-01-14 | | Release date: | 2019-01-23 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (3.18 Å) | | Cite: | Crystal Structure of T2R-TTL complex with 7a3
To Be Published
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5TJB
 | | I-II linker of TRPML1 channel at pH 4.5 | | Descriptor: | Mucolipin-1 | | Authors: | Li, M, Zhang, W.K, Benvin, N.M, Zhou, X, Su, D, Li, H, Wang, S, Michailidis, I.E, Tong, L, Li, X, Yang, J. | | Deposit date: | 2016-10-04 | | Release date: | 2017-01-25 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural basis of dual Ca(2+)/pH regulation of the endolysosomal TRPML1 channel.
Nat. Struct. Mol. Biol., 24, 2017
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6AYG
 | | Human Apo-TRPML3 channel at pH 4.8 | | Descriptor: | Mucolipin-3 | | Authors: | Zhou, X, Li, M, Su, D, Jia, Q, Li, H, Li, X, Yang, J. | | Deposit date: | 2017-09-08 | | Release date: | 2017-11-08 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (4.65 Å) | | Cite: | Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states.
Nat. Struct. Mol. Biol., 24, 2017
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6AYE
 | | Human apo-TRPML3 channel at pH 7.4 | | Descriptor: | Mucolipin-3 | | Authors: | Zhou, X, Li, M, Su, D, Jia, Q, Li, H, Li, X, Yang, J. | | Deposit date: | 2017-09-08 | | Release date: | 2017-11-08 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (4.06 Å) | | Cite: | Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states.
Nat. Struct. Mol. Biol., 24, 2017
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7CE8
 | | Crystal structure of T2R-TTL-Compound11 complex | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GLYCEROL, ... | | Authors: | Chen, L.J, Chen, Q, Yu, Y, Yang, J.H. | | Deposit date: | 2020-06-22 | | Release date: | 2021-06-23 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.725 Å) | | Cite: | Small Molecules Promote Selective Denaturation and Degradation of Tubulin Heterodimers through a Low-Barrier Hydrogen Bond.
J.Med.Chem., 65, 2022
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5V56
 | | 2.9A XFEL structure of the multi-domain human smoothened receptor (with E194M mutation) in complex with TC114 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FLAVIN MONONUCLEOTIDE, N-methyl-N-[1-[4-(2-methylpyrazol-3-yl)phthalazin-1-yl]piperidin-4-yl]-4-nitro-2-(trifluoromethyl)benzamide, ... | | Authors: | Zhang, X, Zhao, F, Wu, Y, Yang, J, Han, G.W, Zhao, S, Ishchenko, A, Ye, L, Lin, X, Ding, K, Dharmarajan, V, Griffin, P.R, Gati, C, Nelson, G, Hunter, M.S, Hanson, M.A, Cherezov, V, Stevens, R.C, Tan, W, Tao, H, Xu, F. | | Deposit date: | 2017-03-13 | | Release date: | 2017-05-24 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand.
Nat Commun, 8, 2017
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5V57
 | | 3.0A SYN structure of the multi-domain human smoothened receptor in complex with TC114 | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, FLAVIN MONONUCLEOTIDE, N-methyl-N-[1-[4-(2-methylpyrazol-3-yl)phthalazin-1-yl]piperidin-4-yl]-4-nitro-2-(trifluoromethyl)benzamide, ... | | Authors: | Zhang, X, Zhao, F, Wu, Y, Yang, J, Han, G.W, Zhao, S, Ishchenko, A, Ye, L, Lin, X, Ding, K, Dharmarajan, V, Griffin, P.R, Gati, C, Nelson, G, Hunter, M.S, Hanson, M.A, Cherezov, V, Stevens, R.C, Tan, W, Tao, H, Xu, F. | | Deposit date: | 2017-03-13 | | Release date: | 2017-05-24 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand.
Nat Commun, 8, 2017
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5TJA
 | | I-II linker of TRPML1 channel at pH 6 | | Descriptor: | Mucolipin-1 | | Authors: | Li, M, Zhang, W.K, Benvin, N.M, Zhou, X, Su, D, Li, H, Wang, S, Michailidis, I.E, Tong, L, Li, X, Yang, J. | | Deposit date: | 2016-10-04 | | Release date: | 2017-01-25 | | Last modified: | 2019-12-18 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural basis of dual Ca(2+)/pH regulation of the endolysosomal TRPML1 channel.
Nat. Struct. Mol. Biol., 24, 2017
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5TJC
 | | I-II linker of TRPML1 channel at pH 7.5 | | Descriptor: | Mucolipin-1 | | Authors: | Li, M, Zhang, W.K, Benvin, N.M, Zhou, X, Su, D, Li, H, Wang, S, Michailidis, I.E, Tong, L, Li, X, Yang, J. | | Deposit date: | 2016-10-04 | | Release date: | 2017-01-25 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural basis of dual Ca(2+)/pH regulation of the endolysosomal TRPML1 channel.
Nat. Struct. Mol. Biol., 24, 2017
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