5KJV
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![BU of 5kjv by Molmil](/molmil-images/mine/5kjv) | Crystal structure of Coleus blumei HCT | Descriptor: | Hydroxycinnamoyl transferase | Authors: | Levsh, O, Chiang, Y.C, Tung, C.F, Noel, J.P, Wang, Y, Weng, J.K. | Deposit date: | 2016-06-20 | Release date: | 2016-11-02 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Dynamic Conformational States Dictate Selectivity toward the Native Substrate in a Substrate-Permissive Acyltransferase. Biochemistry, 55, 2016
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1JR6
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5DGW
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![BU of 5dgw by Molmil](/molmil-images/mine/5dgw) | Crystal Structure of HIV-1 Protease Inhibitor GRL-105-11A Containing Substituted fused-Tetrahydropyranyl Tetrahydrofuran as P2-Ligand | Descriptor: | (3R,3aS,4S,7aS)-3-(ethylamino)hexahydro-4H-furo[2,3-b]pyran-4-yl [(2S,3R)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}-1-phenylbutan-2-yl]carbamate, CHLORIDE ION, Pol protein, ... | Authors: | Agniswamy, J, Wang, Y.-F, Weber, I.T. | Deposit date: | 2015-08-28 | Release date: | 2015-10-28 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.62 Å) | Cite: | Design, synthesis, biological evaluation and X-ray structural studies of HIV-1 protease inhibitors containing substituted fused-tetrahydropyranyl tetrahydrofuran as P2-ligands. Org.Biomol.Chem., 13, 2015
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6PDR
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6PDU
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![BU of 6pdu by Molmil](/molmil-images/mine/6pdu) | Vaccine-elicited NHP FP-targeting antibody 13N024-a.01 in complex with HIV fusion peptide (residue 512-519) | Descriptor: | HIV-1 fusion peptide residue 512-519, antibody 13N024-a.01, heavy chain, ... | Authors: | Xu, K, Liu, K, Wang, Y, Kwong, P.D. | Deposit date: | 2019-06-19 | Release date: | 2020-06-24 | Method: | X-RAY DIFFRACTION (1.953 Å) | Cite: | Modular recognition of antigens provides a mechanism that improves vaccine-elicited antibody-class frequencies To Be Published
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1T2L
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![BU of 1t2l by Molmil](/molmil-images/mine/1t2l) | Three Crystal Structures of Human Coactosin-like Protein | Descriptor: | Coactosin-like protein | Authors: | Liu, L, Wei, Z, Chen, Z, Wang, Y, Gong, W. | Deposit date: | 2004-04-22 | Release date: | 2004-11-23 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal Structure of Human Coactosin-like Protein J.Mol.Biol., 344, 2004
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1T3X
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1T3Y
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1SVS
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![BU of 1svs by Molmil](/molmil-images/mine/1svs) | Structure of the K180P mutant of Gi alpha subunit bound to GppNHp. | Descriptor: | Guanine nucleotide-binding protein G(i), alpha-1 subunit, MAGNESIUM ION, ... | Authors: | Thomas, C.J, Du, X, Li, P, Wang, Y, Ross, E.M, Sprang, S.R. | Deposit date: | 2004-03-29 | Release date: | 2004-06-01 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Uncoupling conformational change from GTP hydrolysis in a heterotrimeric G protein {alpha}-subunit. Proc.Natl.Acad.Sci.USA, 101, 2004
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1SVK
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![BU of 1svk by Molmil](/molmil-images/mine/1svk) | Structure of the K180P mutant of Gi alpha subunit bound to AlF4 and GDP | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i), alpha-1 subunit, ... | Authors: | Thomas, C.J, Du, X, Li, P, Wang, Y, Ross, E.M, Sprang, S.R. | Deposit date: | 2004-03-29 | Release date: | 2004-06-01 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Uncoupling conformational change from GTP hydrolysis in a heterotrimeric G protein {alpha}-subunit. Proc.Natl.Acad.Sci.USA, 101, 2004
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1TCS
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5KPP
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![BU of 5kpp by Molmil](/molmil-images/mine/5kpp) | Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor | Descriptor: | 1-[[4-fluoranyl-3-[(3R)-3-methyl-4-[2,2,2-tris(fluoranyl)ethyl]piperazin-1-yl]carbonyl-phenyl]methyl]quinazoline-2,4-dione, Poly [ADP-ribose] polymerase 1 | Authors: | Cao, R, Wang, Y.L, Zhou, J, Huang, N, Xu, B.L. | Deposit date: | 2016-07-05 | Release date: | 2016-11-30 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.33 Å) | Cite: | Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor To Be Published
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6VWT
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8K58
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![BU of 8k58 by Molmil](/molmil-images/mine/8k58) | The cryo-EM map of close TIEA-TIC complex | Descriptor: | 15 kDa RNA polymerase-binding protein, DNA (29-MER), DNA-directed RNA polymerase subunit alpha, ... | Authors: | Zhang, K.N, Liu, Y, Chen, M, Wang, Y, Lin, W, Li, M, Zhang, X, Gao, Y, Gong, Q, Chen, H, Steve, M, Li, S, Zhang, K, Liu, B. | Deposit date: | 2023-07-21 | Release date: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.15 Å) | Cite: | TIEA inhibits Sigma70-dependent transcriptions, accelerates elongation speed and elevates transcription error To Be Published
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8K5A
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![BU of 8k5a by Molmil](/molmil-images/mine/8k5a) | The cryo-EM map of open TIEA-TIC complex | Descriptor: | 15 kDa RNA polymerase-binding protein, DNA (29-MER), DNA-directed RNA polymerase subunit alpha, ... | Authors: | Zhang, K.N, Liu, Y, Chen, M, Wang, Y, Lin, W, Li, M, Zhang, X, Gao, Y, Gong, Q, Chen, H, Steve, M, Li, S, Zhang, K, Liu, B. | Deposit date: | 2023-07-21 | Release date: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | TIEA inhibits sigma70-dependent transcriptions, accelerates elongation speed and elevates transcription error To Be Published
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139D
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6IIM
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![BU of 6iim by Molmil](/molmil-images/mine/6iim) | USP14 catalytic domain with IU1-206 | Descriptor: | 1-[1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(4-hydroxypiperidin-1-yl)ethan-1-one, Ubiquitin carboxyl-terminal hydrolase 14 | Authors: | Mei, Z.Q, Wang, J.W, Wang, F, Wang, Y.W. | Deposit date: | 2018-10-07 | Release date: | 2018-12-12 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade. Cell Res., 28, 2018
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6IIN
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![BU of 6iin by Molmil](/molmil-images/mine/6iin) | USP14 catalytic domain with IU1-248 | Descriptor: | 4-{3-[(4-hydroxypiperidin-1-yl)acetyl]-2,5-dimethyl-1H-pyrrol-1-yl}benzonitrile, Ubiquitin carboxyl-terminal hydrolase 14 | Authors: | Mei, Z.Q, Wang, J.W, Wang, F, Wang, Y.W. | Deposit date: | 2018-10-07 | Release date: | 2018-12-19 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.53 Å) | Cite: | Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade. Cell Res., 28, 2018
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6IIL
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![BU of 6iil by Molmil](/molmil-images/mine/6iil) | USP14 catalytic domain bind to IU1-47 | Descriptor: | 1-[1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(piperidin-1-yl)ethan-1-one, Ubiquitin carboxyl-terminal hydrolase 14 | Authors: | Mei, Z.Q, Wang, Y.W, Wang, F, Wang, J.W, He, W, Ding, S, Li, J.W. | Deposit date: | 2018-10-07 | Release date: | 2018-12-12 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade. Cell Res., 28, 2018
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6J76
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![BU of 6j76 by Molmil](/molmil-images/mine/6j76) | Structure of 3,6-anhydro-L-galactose Dehydrogenase in Complex with NAP | Descriptor: | Aldehyde dehydrogenase A, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Li, P.Y, Wang, Y, Chen, X.L, Zhang, Y.Z. | Deposit date: | 2019-01-17 | Release date: | 2020-01-22 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.368 Å) | Cite: | 3,6-Anhydro-L-Galactose Dehydrogenase VvAHGD is a Member of a New Aldehyde Dehydrogenase Family and Catalyzes by a Novel Mechanism with Conformational Switch of Two Catalytic Residues Cysteine 282 and Glutamate 248. J.Mol.Biol., 432, 2020
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8IFG
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![BU of 8ifg by Molmil](/molmil-images/mine/8ifg) | Cryo-EM structure of the Clr6S (Clr6-HDAC) complex from S. pombe | Descriptor: | Chromatin modification-related protein eaf3, Cph1, Cph2, ... | Authors: | Zhang, H.Q, Wang, X, Wang, Y.N, Liu, S.M, Zhang, Y, Xu, K, Ji, L.T, Kornberg, R.D. | Deposit date: | 2023-02-17 | Release date: | 2024-01-03 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Class I histone deacetylase complex: Structure and functional correlates. Proc Natl Acad Sci U S A, 120, 2023
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6JE9
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![BU of 6je9 by Molmil](/molmil-images/mine/6je9) | Crystal structure of Nme1Cas9-sgRNA dimer mediated by double protein inhibitor AcrIIC3 monomers | Descriptor: | AcrIIC3, CRISPR-associated endonuclease Cas9, sgRNA | Authors: | Sun, W, Yang, J, Cheng, Z, Liu, C, Wang, K, Huang, X, Wang, Y. | Deposit date: | 2019-02-04 | Release date: | 2019-11-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.46 Å) | Cite: | Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States. Mol.Cell, 76, 2019
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6J0B
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![BU of 6j0b by Molmil](/molmil-images/mine/6j0b) | Cryo-EM Structure of an Extracellular Contractile Injection System, PVC sheath-tube complex in extended state | Descriptor: | Pvc1, Pvc2 | Authors: | Jiang, F, Li, N, Wang, X, Cheng, J, Huang, Y, Yang, Y, Yang, J, Cai, B, Wang, Y, Jin, Q, Gao, N. | Deposit date: | 2018-12-23 | Release date: | 2019-04-10 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Cryo-EM Structure and Assembly of an Extracellular Contractile Injection System. Cell, 177, 2019
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6J0C
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![BU of 6j0c by Molmil](/molmil-images/mine/6j0c) | Cryo-EM Structure of an Extracellular Contractile Injection System, PVC sheath complex in contracted state | Descriptor: | Pvc2 | Authors: | Jiang, F, Li, N, Wang, X, Cheng, J, Huang, Y, Yang, Y, Yang, J, Cai, B, Wang, Y, Jin, Q, Gao, N. | Deposit date: | 2018-12-23 | Release date: | 2019-04-10 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Cryo-EM Structure and Assembly of an Extracellular Contractile Injection System. Cell, 177, 2019
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6J0F
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![BU of 6j0f by Molmil](/molmil-images/mine/6j0f) | Cryo-EM Structure of an Extracellular Contractile Injection System, PVC sheath/tube terminator in extended state | Descriptor: | Pvc1, Pvc16 | Authors: | Jiang, F, Li, N, Wang, X, Cheng, J, Huang, Y, Yang, Y, Yang, J, Cai, B, Wang, Y, Jin, Q, Gao, N. | Deposit date: | 2018-12-24 | Release date: | 2019-04-10 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Cryo-EM Structure and Assembly of an Extracellular Contractile Injection System. Cell, 177, 2019
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