1JR6

Solution Structure of an Engineered Arginine-rich Subdomain 2 of the Hepatitis C Virus NS3 RNA Helicase

Summary for 1JR6

• Entry DOI: 10.2210/pdb1jr6/pdb
• NMR Information: BMRB: 4791
• Descriptor: Helicase NS3 (1 entity in total)
• Functional Keywords: alpha-beta-alpha, hydrolase
• Biological source: Hepatitis C virus
• Cellular location: Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein. Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein. Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein. RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P27958
• Total number of polymer chains: 1
• Total formula weight: 15149.27

Authors

Liu, D.,Wyss, D.F.,Wang, Y.S.,Gesell, J.J. (deposition date: 2001-08-10, release date: 2002-08-10, Last modification date: 2022-02-23)

• Primary citation: Liu, D.,Wang, Y.S.,Gesell, J.J.,Wyss, D.F.; Solution structure and backbone dynamics of an engineered arginine-rich subdomain 2 of the hepatitis C virus NS3 RNA helicase.; J.Mol.Biol., 314:543-561, 2001; PubMed: 11846566; DOI: 10.1006/jmbi.2001.5146

Experimental method

SOLUTION NMR