6IIN

USP14 catalytic domain with IU1-248

Summary for 6IIN

Entry DOI	10.2210/pdb6iin/pdb
Descriptor	Ubiquitin carboxyl-terminal hydrolase 14, 4-{3-[(4-hydroxypiperidin-1-yl)acetyl]-2,5-dimethyl-1H-pyrrol-1-yl}benzonitrile (3 entities in total)
Functional Keywords	usp14 inhibitor complex, structural protein, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	88733.07
Authors	Mei, Z.Q.,Wang, J.W.,Wang, F.,Wang, Y.W. (deposition date: 2018-10-07, release date: 2018-12-19, Last modification date: 2024-03-27)
Primary citation	Wang, Y.,Jiang, Y.,Ding, S.,Li, J.,Song, N.,Ren, Y.,Hong, D.,Wu, C.,Li, B.,Wang, F.,He, W.,Wang, J.,Mei, Z. Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade. Cell Res., 28:1186-1194, 2018 Cited by PubMed: 30254335 DOI: 10.1038/s41422-018-0091-x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.53 Å)

Structure validation