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5KPP

Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor

Summary for 5KPP
Entry DOI10.2210/pdb5kpp/pdb
Related5KPN 5KPO 5KPQ
DescriptorPoly [ADP-ribose] polymerase 1, 1-[[4-fluoranyl-3-[(3R)-3-methyl-4-[2,2,2-tris(fluoranyl)ethyl]piperazin-1-yl]carbonyl-phenyl]methyl]quinazoline-2,4-dione (3 entities in total)
Functional Keywordsinhibitor, complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationNucleus: P09874
Total number of polymer chains2
Total formula weight79294.50
Authors
Cao, R.,Wang, Y.L.,Zhou, J.,Huang, N.,Xu, B.L. (deposition date: 2016-07-05, release date: 2016-11-30, Last modification date: 2024-03-20)
Primary citationCao, R.,Wang, Y.L.,Zhou, J.,Huang, N.,Xu, B.L.
Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor
To Be Published,
Experimental method
X-RAY DIFFRACTION (2.33 Å)
Structure validation

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