6JE9
Crystal structure of Nme1Cas9-sgRNA dimer mediated by double protein inhibitor AcrIIC3 monomers
Summary for 6JE9
Entry DOI | 10.2210/pdb6je9/pdb |
Descriptor | CRISPR-associated endonuclease Cas9, sgRNA, AcrIIC3 (3 entities in total) |
Functional Keywords | crispr-cas9, nmecas9, nme1cas9, acriic3, anti-crispr, hydrolase, dimer, hydrolase-hydrolase inhibitor-rna complex, hydrolase/hydrolase inhibitor/rna |
Biological source | Neisseria meningitidis 8013 More |
Total number of polymer chains | 6 |
Total formula weight | 364903.84 |
Authors | |
Primary citation | Sun, W.,Yang, J.,Cheng, Z.,Amrani, N.,Liu, C.,Wang, K.,Ibraheim, R.,Edraki, A.,Huang, X.,Wang, M.,Wang, J.,Liu, L.,Sheng, G.,Yang, Y.,Lou, J.,Sontheimer, E.J.,Wang, Y. Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States. Mol.Cell, 76:938-, 2019 Cited by PubMed: 31668930DOI: 10.1016/j.molcel.2019.09.025 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.46 Å) |
Structure validation
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