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PDB: 191 件
5D65
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X-RAY STRUCTURE OF MACROPHAGE INFLAMMATORY PROTEIN-1 ALPHA (CCL3) WITH HEPARIN COMPLEX
分子名称: 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, C-C motif chemokine 3, CHLORIDE ION, ...
著者Liang, W.G, Hwang, D.Y, Zulueta, M.M, Hung, S.C, Tang, W.
登録日2015-08-11
公開日2016-04-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structural basis for oligomerization and glycosaminoglycan binding of CCL5 and CCL3.
Proc.Natl.Acad.Sci.USA, 113, 2016
1SK6
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BU of 1sk6 by Molmil
Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin, 3',5' cyclic AMP (cAMP), and pyrophosphate
分子名称: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CALCIUM ION, Calmodulin, ...
著者Guo, Q, Shen, Y, Zhukovskaya, N.L, Tang, W.J.
登録日2004-03-04
公開日2004-06-08
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structural and kinetic analyses of the interaction of anthrax adenylyl cyclase toxin with reaction products cAMP and pyrophosphate.
J.Biol.Chem., 279, 2004
1PK0
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BU of 1pk0 by Molmil
Crystal Structure of the EF3-CaM complexed with PMEApp
分子名称: (ADENIN-9-YL-ETHOXYMETHYL)-HYDROXYPHOSPHINYL-DIPHOSPHATE, CALCIUM ION, Calmodulin, ...
著者Shen, Y, Tang, W.J.
登録日2003-06-04
公開日2004-02-10
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection.
Proc.Natl.Acad.Sci.USA, 101, 2004
2X6L
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BU of 2x6l by Molmil
X-ray Structure of Macrophage Inflammatory Protein-1 beta
分子名称: C-C MOTIF CHEMOKINE 4, GLYCEROL
著者Guo, Q, Ren, M, Tang, W.
登録日2010-02-17
公開日2010-11-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.602 Å)
主引用文献Polymerization of Mip-1 Chemokine (Ccl3 and Ccl4) and Clearance of Mip-1 by Insulin-Degrading Enzyme.
Embo J., 29, 2010
2WBY
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BU of 2wby by Molmil
Crystal structure of human insulin-degrading enzyme in complex with insulin
分子名称: INSULIN A CHAIN, INSULIN B CHAIN, INSULIN-DEGRADING ENZYME, ...
著者Manolopoulou, M, Guo, Q, Malito, E, Schilling, A.B, Tang, W.J.
登録日2009-03-06
公開日2009-03-24
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Molecular Basis of Catalytic Chamber-Assisted Unfolding and Cleavage of Human Insulin by Human Insulin Degrading Enzyme.
J.Biol.Chem., 284, 2009
2WK3
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BU of 2wk3 by Molmil
Crystal structure of human insulin-degrading enzyme in complex with amyloid-beta (1-42)
分子名称: BETA-AMYLOID PROTEIN 42, INSULIN DEGRADING ENZYME, ZINC ION
著者Guo, Q, Tang, W.J.
登録日2009-06-05
公開日2009-11-03
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.59 Å)
主引用文献Molecular Basis for the Recognition and Cleavages of Igf-II, Tgf-Alpha, and Amylin by Human Insulin Degrading Enzyme.
J.Mol.Biol., 395, 2010
2WC0
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BU of 2wc0 by Molmil
crystal structure of human insulin degrading enzyme in complex with iodinated insulin
分子名称: 1,4-DIETHYLENE DIOXIDE, INSULIN A CHAIN, INSULIN B CHAIN, ...
著者Manolopoulou, M, Guo, Q, Malito, E, Schilling, A.B, Tang, W.J.
登録日2009-03-06
公開日2009-03-24
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Molecular Basis of Catalytic Chamber-Assisted Unfolding and Cleavage of Human Insulin by Human Insulin Degrading Enzyme.
J.Biol.Chem., 284, 2009
2X69
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BU of 2x69 by Molmil
X-ray Structure of Macrophage Inflammatory Protein-1 alpha polymer
分子名称: C-C MOTIF CHEMOKINE 3
著者Guo, Q, Ren, M, Tang, W.
登録日2010-02-15
公開日2010-11-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Polymerization of Mip-1 Chemokine (Ccl3 and Ccl4) and Clearance of Mip-1 by Insulin-Degrading Enzyme.
Embo J., 29, 2010
3E4Z
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BU of 3e4z by Molmil
Crystal structure of human insulin degrading enzyme in complex with insulin-like growth factor II
分子名称: Insulin-degrading enzyme, Insulin-like growth factor II, ZINC ION
著者Guo, Q, Manolopoulou, M, Tang, W.-J.
登録日2008-08-12
公開日2009-08-18
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-alpha, and Amylin by Human Insulin-Degrading Enzyme.
J.Mol.Biol., 395, 2010
3E50
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BU of 3e50 by Molmil
Crystal structure of human insulin degrading enzyme in complex with transforming growth factor-alpha
分子名称: Insulin-degrading enzyme, Protransforming growth factor alpha, ZINC ION
著者Guo, Q, Manolopoulou, M, Tang, W.-J.
登録日2008-08-12
公開日2009-08-18
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-alpha, and Amylin by Human Insulin-Degrading Enzyme.
J.Mol.Biol., 395, 2010
7RZI
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BU of 7rzi by Molmil
Insulin Degrading Enzyme pC/pC
分子名称: Cysteine-free Insulin-degrading enzyme, Insulin A chain, Insulin B chain
著者Mancl, J.M, Liang, W.G, Tang, W.J.
登録日2021-08-27
公開日2022-08-31
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme
To be published
7RZH
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BU of 7rzh by Molmil
Insulin Degrading Enzyme O/O
分子名称: Cysteine-free Insulin-degrading enzyme
著者Mancl, J.M, Liang, W.G, Tang, W.J.
登録日2021-08-27
公開日2022-08-31
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme
To be published
7RZE
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BU of 7rze by Molmil
Insulin Degrading Enzyme pO/pC
分子名称: Cysteine-free Insulin-degrading enzyme, Insulin A chain, Insulin B chain
著者Mancl, J.M, Liang, W.G, Tang, W.J.
登録日2021-08-27
公開日2022-08-31
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme
To be published
7RZF
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BU of 7rzf by Molmil
Insulin Degrading Enzyme O/pC
分子名称: Cysteine-free Insulin-degrading enzyme, Insulin A chain, Insulin B chain
著者Mancl, J.M, Liang, W.G, Tang, W.J.
登録日2021-08-27
公開日2022-08-31
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme
To be published
7RZG
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BU of 7rzg by Molmil
Insulin Degrading Enzyme O/pO
分子名称: Cysteine-free Insulin-degrading enzyme
著者Mancl, J.M, Liang, W.G, Tang, W.J.
登録日2021-08-27
公開日2022-08-31
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme
To be published
5CJO
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BU of 5cjo by Molmil
Crystal Structure Analysis of Elbow-Engineered-Fab-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Insulin
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, FAB Heavy chain with engineered elbow, FAB light chain, ...
著者liang, w.g, bailey, L, tang, w.j.
登録日2015-07-14
公開日2016-07-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.287 Å)
主引用文献Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination.
J. Mol. Biol., 2017
1I5U
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BU of 1i5u by Molmil
SOLUTION STRUCTURE OF CYTOCHROME B5 TRIPLE MUTANT (E48A/E56A/D60A)
分子名称: CYTOCHROME B5, PROTOPORPHYRIN IX CONTAINING FE
著者Qian, C, Yao, Y, Tang, W, Wang, J, Zhongxian, H.
登録日2001-02-28
公開日2001-03-21
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Effects of charged amino-acid mutation on the solution structure of cytochrome b(5) and binding between cytochrome b(5) and cytochrome c.
Protein Sci., 10, 2001
1K90
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BU of 1k90 by Molmil
Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin and 3' deoxy-ATP
分子名称: 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, CALMODULIN, ...
著者Drum, C.L, Yan, S.-Z, Bard, J, Shen, Y.-Q, Lu, D, Soelaiman, S, Grabarek, Z, Bohm, A, Tang, W.-J.
登録日2001-10-26
公開日2002-01-23
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin.
Nature, 415, 2002
4NXO
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BU of 4nxo by Molmil
Crystal Structure of Insulin Degrading Enzyme in complex with BDM44768
分子名称: 1,2-ETHANEDIOL, 1,4-DIETHYLENE DIOXIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
著者Liang, W.G, Deprez, R, Deprez, B, Tang, W.
登録日2013-12-09
公開日2015-10-07
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.73 Å)
主引用文献Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice.
Nat Commun, 6, 2015
3E4A
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BU of 3e4a by Molmil
Human IDE-inhibitor complex at 2.6 angstrom resolution
分子名称: 1,4-DIETHYLENE DIOXIDE, ACETIC ACID, HYDROXAMATE PEPTIDE II1, ...
著者Malito, E, Leissring, M.A, Choi, S, Cuny, G.D, Tang, W.J.
登録日2008-08-11
公開日2009-05-19
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin.
Plos One, 5, 2010
1FI7
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BU of 1fi7 by Molmil
Solution structure of the imidazole complex of cytochrome C
分子名称: CYTOCHROME C, HEME C, IMIDAZOLE
著者Banci, L, Bertini, I, Liu, G, Lu, J, Reddig, T, Tang, W, Wu, Y, Zhu, D.
登録日2000-08-03
公開日2000-08-23
最終更新日2022-02-23
実験手法SOLUTION NMR
主引用文献Effects of extrinsic imidazole ligation on the molecular and electronic structure of cytochrome c
J.Biol.Inorg.Chem., 6, 2001
1XFZ
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Crystal structure of anthrax edema factor (EF) in complex with calmodulin in the presence of 1 millimolar exogenously added calcium chloride
分子名称: CALCIUM ION, Calmodulin 2, Calmodulin-sensitive adenylate cyclase, ...
著者Shen, Y, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J.
登録日2004-09-15
公開日2005-05-03
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (3.25 Å)
主引用文献Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
1FI9
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BU of 1fi9 by Molmil
SOLUTION STRUCTURE OF THE IMIDAZOLE COMPLEX OF CYTOCHROME C
分子名称: CYTOCHROME C, HEME C, IMIDAZOLE
著者Banci, L, Bertini, I, Liu, G, Lu, J, Reddig, T, Tang, W, Wu, Y, Zhu, D.
登録日2000-08-03
公開日2000-08-23
最終更新日2022-02-23
実験手法SOLUTION NMR
主引用文献Effects of extrinsic imidazole ligation on the molecular and electronic structure of cytochrome c
J.Biol.Inorg.Chem., 6, 2001
1XFU
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Crystal structure of anthrax edema factor (EF) truncation mutant, EF-delta 64 in complex with calmodulin
分子名称: CALCIUM ION, Calmodulin 2, Calmodulin-sensitive adenylate cyclase, ...
著者Shen, Y, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J.
登録日2004-09-15
公開日2005-05-03
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (3.35 Å)
主引用文献Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
1Y0V
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Crystal structure of anthrax edema factor (EF) in complex with calmodulin and pyrophosphate
分子名称: CALCIUM ION, Calmodulin, Calmodulin-sensitive adenylate cyclase, ...
著者Shen, Y, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.-J.
登録日2004-11-16
公開日2005-05-03
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor
Embo J., 24, 2005

223790

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