7RZH
Insulin Degrading Enzyme O/O
Summary for 7RZH
| Entry DOI | 10.2210/pdb7rzh/pdb |
| EMDB information | 24760 |
| Descriptor | Cysteine-free Insulin-degrading enzyme (1 entity in total) |
| Functional Keywords | m16a zinc metalloprotease, hydrolase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 234137.02 |
| Authors | Mancl, J.M.,Liang, W.G.,Tang, W.J. (deposition date: 2021-08-27, release date: 2022-08-31, Last modification date: 2026-06-10) |
| Primary citation | Mancl, J.M.,Liang, W.G.,Bayhi, N.L.,Wei, H.,Budell, W.,Mendez, J.H.,Sosnick, T.R.,Carragher, B.,Potter, C.S.,Tang, W.J. Characterization and modulation of human insulin degrading enzyme conformational dynamics to control enzyme activity Elife, 2026 Cited by DOI: 10.7554/elife.105761.3PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (3.8 Å) |
Structure validation
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