7RZH
Insulin Degrading Enzyme O/O
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Cysteine-free Insulin-degrading enzyme | polymer | 1011 | 117068.5 | 2 | UniProt (P14735) Pfam (PF00675) Pfam (PF05193) Pfam (PF16187) | Homo sapiens (Human) | Abeta-degrading protease,Insulin protease,Insulinase,Insulysin |
Sequence modifications
A, B: 1 - 1011 (UniProt: P14735)
| PDB | External Database | Details |
|---|---|---|
| Leu 110 | Cys 110 | engineered mutation |
| Ser 171 | Cys 171 | engineered mutation |
| Ala 178 | Cys 178 | engineered mutation |
| Val 257 | Cys 257 | engineered mutation |
| Leu 414 | Cys 414 | engineered mutation |
| Asn 573 | Cys 573 | engineered mutation |
| Ser 590 | Cys 590 | engineered mutation |
| Ser 789 | Cys 789 | engineered mutation |
| Ala 812 | Cys 812 | engineered mutation |
| Ala 819 | Cys 819 | engineered mutation |
| Ser 904 | Cys 904 | engineered mutation |
| Ser 966 | Cys 966 | engineered mutation |
| Ser 974 | Cys 974 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 234137.0 | |
| All* | Total formula weight | 234137.0 |
