1TT5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1tt5 by Molmil](/molmil-images/mine/1tt5) | Structure of APPBP1-UBA3-Ubc12N26: a unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8 | Descriptor: | Ubiquitin-conjugating enzyme E2 M, ZINC ION, amyloid protein-binding protein 1, ... | Authors: | Huang, D.T, Miller, D.W, Mathew, R, Cassell, R, Holton, J.M, Roussel, M.F, Schulman, B.A. | Deposit date: | 2004-06-21 | Release date: | 2004-09-14 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8. Nat.Struct.Mol.Biol., 11, 2004
|
|
7Q4Y
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7q4y by Molmil](/molmil-images/mine/7q4y) | |
7Q51
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7q51 by Molmil](/molmil-images/mine/7q51) | yeast Gid10 bound to a Phe/N-peptide | Descriptor: | CHLORIDE ION, FWLPANLW peptide, Uncharacterized protein YGR066C | Authors: | Chrustowicz, J, Sherpa, D, Prabu, J.R, Schulman, B.A. | Deposit date: | 2021-11-02 | Release date: | 2022-03-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.22 Å) | Cite: | Multifaceted N-Degron Recognition and Ubiquitylation by GID/CTLH E3 Ligases. J.Mol.Biol., 434, 2022
|
|
7Q50
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7q50 by Molmil](/molmil-images/mine/7q50) | human Gid4 bound to a Phe/N-peptide | Descriptor: | FDVSWFMG peptide, Glucose-induced degradation protein 4 homolog | Authors: | Chrustowicz, J, Sherpa, D, Loke, M.S, Prabu, J.R, Schulman, B.A. | Deposit date: | 2021-11-02 | Release date: | 2022-03-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.16 Å) | Cite: | Multifaceted N-Degron Recognition and Ubiquitylation by GID/CTLH E3 Ligases. J.Mol.Biol., 434, 2022
|
|
5L9U
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5l9u by Molmil](/molmil-images/mine/5l9u) | Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with a cross linked Ubiquitin variant-substrate-UBE2C (UBCH10) complex representing key features of multiubiquitination | Descriptor: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | Authors: | Brown, N.G, VanderLinden, R, Dube, P, Haselbach, D, Peters, J.M, Stark, H, Schulman, B.A. | Deposit date: | 2016-06-11 | Release date: | 2016-09-14 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (6.4 Å) | Cite: | Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C. Cell, 165, 2016
|
|
5L9T
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5l9t by Molmil](/molmil-images/mine/5l9t) | Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with E2 UBE2S poised for polyubiquitination where UBE2S, APC2, and APC11 are modeled into low resolution density | Descriptor: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | Authors: | Brown, N.G, VanderLinden, R, Dube, P, Haselbach, D, Peters, J.M, Stark, H, Schulman, B.A. | Deposit date: | 2016-06-11 | Release date: | 2016-10-26 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (6.4 Å) | Cite: | Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C. Cell, 165, 2016
|
|
8EBM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8ebm by Molmil](/molmil-images/mine/8ebm) | |
8EBL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8ebl by Molmil](/molmil-images/mine/8ebl) | |
6TTU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ttu by Molmil](/molmil-images/mine/6ttu) | Ubiquitin Ligation to substrate by a cullin-RING E3 ligase at 3.7A resolution: NEDD8-CUL1-RBX1 N98R-SKP1-monomeric b-TRCP1dD-IkBa-UB~UBE2D2 | Descriptor: | CYS-LYS-LYS-ALA-ARG-HIS-ASP-SEP-GLY, Cullin-1, E3 ubiquitin-protein ligase RBX1, ... | Authors: | Baek, K, Prabu, J.R, Schulman, B.A. | Deposit date: | 2019-12-30 | Release date: | 2020-02-12 | Last modified: | 2020-03-04 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | NEDD8 nucleates a multivalent cullin-RING-UBE2D ubiquitin ligation assembly. Nature, 578, 2020
|
|
8CDK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8cdk by Molmil](/molmil-images/mine/8cdk) | |
8CDJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8cdj by Molmil](/molmil-images/mine/8cdj) | CAND1 b-hairpin++-SCF-SKP2 CAND1 rolling SCF engaged | Descriptor: | Cullin-1, Cullin-associated NEDD8-dissociated protein 1, E3 ubiquitin-protein ligase RBX1, ... | Authors: | Baek, K, Schulman, B.A. | Deposit date: | 2023-01-31 | Release date: | 2023-04-19 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Systemwide disassembly and assembly of SCF ubiquitin ligase complexes. Cell, 186, 2023
|
|
8C07
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8c07 by Molmil](/molmil-images/mine/8c07) | |
8Q7R
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8q7r by Molmil](/molmil-images/mine/8q7r) | Ubiquitin ligation to substrate by a cullin-RING E3 ligase & Cdc34: NEDD8-CUL2-RBX1-ELOB/C-FEM1C with trapped UBE2R2~donor UB-Sil1 peptide | Descriptor: | 5-azanyl-1-oxidanyl-pentan-2-one, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... | Authors: | Liwocha, J, Prabu, J.R, Kleiger, G, Schulman, B.A. | Deposit date: | 2023-08-16 | Release date: | 2024-02-21 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.71 Å) | Cite: | Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting. Mol.Cell, 84, 2024
|
|
8OIF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8oif by Molmil](/molmil-images/mine/8oif) | Structure of the UBE1L activating enzyme bound to ISG15 and UBE2L6 | Descriptor: | ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ... | Authors: | Wallace, I, Kheewoong, B, Prabu, J.R, Vollrath, R, von Gronau, S, Schulman, B.A, Swatek, K.N. | Deposit date: | 2023-03-22 | Release date: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Insights into the ISG15 transfer cascade by the UBE1L activating enzyme. Nat Commun, 14, 2023
|
|
8C06
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8c06 by Molmil](/molmil-images/mine/8c06) | |
8CAF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8caf by Molmil](/molmil-images/mine/8caf) | N8C_Fab3b in complex with NEDD8-CUL1(WHB) | Descriptor: | Cullin-1, Fab Heavy Chain, Fab Light Chain, ... | Authors: | Duda, D.M, Yanishevski, D, Henneberg, L.T, Schulman, B.A. | Deposit date: | 2023-01-24 | Release date: | 2023-09-13 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.66 Å) | Cite: | Activity-based profiling of cullin-RING E3 networks by conformation-specific probes. Nat.Chem.Biol., 19, 2023
|
|
8PD0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8pd0 by Molmil](/molmil-images/mine/8pd0) | cryo-EM structure of Doa10 in MSP1E3D1 | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE, ERAD-associated E3 ubiquitin-protein ligase DOA10 | Authors: | Botsch, J.J, Braeuning, B, Schulman, B.A. | Deposit date: | 2023-06-11 | Release date: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (3.58 Å) | Cite: | Doa10/MARCH6 architecture interconnects E3 ligase activity with lipid-binding transmembrane channel to regulate SQLE. Nat Commun, 15, 2024
|
|
8PDA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8pda by Molmil](/molmil-images/mine/8pda) | cryo-EM structure of Doa10 with RING domain in MSP1E3D1 | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE, ERAD-associated E3 ubiquitin-protein ligase DOA10 | Authors: | Botsch, J.J, Braeuning, B, Schulman, B.A. | Deposit date: | 2023-06-12 | Release date: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (3.58 Å) | Cite: | Doa10/MARCH6 architecture interconnects E3 ligase activity with lipid-binding transmembrane channel to regulate SQLE. Nat Commun, 15, 2024
|
|
6BG3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6bg3 by Molmil](/molmil-images/mine/6bg3) | Structure of (3S,4S)-1-benzyl-4-(3-(3-(trifluoromethyl)phenyl)ureido)piperidin-3-yl acetate bound to DCN1 | Descriptor: | Endolysin, DCN1-like protein 1 chimera, N-{(3S,4S)-1-benzyl-3-[(1S)-1-hydroxyethoxy]piperidin-4-yl}-N'-[3-(trifluoromethyl)phenyl]urea | Authors: | Guy, R.K, Schulman, B.A, Scott, D.C, Hammill, J.T. | Deposit date: | 2017-10-27 | Release date: | 2018-09-26 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation. J. Med. Chem., 61, 2018
|
|
6BG5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6bg5 by Molmil](/molmil-images/mine/6bg5) | Structure of 1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-(1-propylpiperidin-4-yl)-3-(3-(trifluoromethyl)phenyl)urea bound to DCN1 | Descriptor: | Endolysin, DCN1-like protein 1 chimera, N-[(2H-1,3-benzodioxol-5-yl)methyl]-N-(1-propylpiperidin-4-yl)-N'-[3-(trifluoromethyl)phenyl]urea | Authors: | Guy, R.K, Schulman, B.A, Scott, D.C, Hammill, J.T. | Deposit date: | 2017-10-27 | Release date: | 2018-09-26 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation. J. Med. Chem., 61, 2018
|
|
6SWY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6swy by Molmil](/molmil-images/mine/6swy) | Structure of active GID E3 ubiquitin ligase complex minus Gid2 and delta Gid9 RING domain | Descriptor: | Glucose-induced degradation protein 8, Protein FYV10,Protein FYV10,Protein FYV10,Protein FYV10,Protein FYV10,Protein FYV10,Protein FYV10, Vacuolar import and degradation protein 24, ... | Authors: | Qiao, S, Prabu, J.R, Schulman, B.A. | Deposit date: | 2019-09-24 | Release date: | 2019-11-20 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly Mol.Cell, 77, 2020
|
|
2MT5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2mt5 by Molmil](/molmil-images/mine/2mt5) | Isolated Ring domain | Descriptor: | Anaphase-promoting complex subunit 11, ZINC ION | Authors: | Brown, N.G, Watson, E.R, Weissman, F, Royappa, G, Schulman, B, Jarvis, M, Vanderlinden, R, Frye, J.J, Qiao, R, Petzold, G, Peters, J, Stark, H. | Deposit date: | 2014-08-13 | Release date: | 2014-10-29 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Mechanism of Polyubiquitination by Human Anaphase-Promoting Complex: RING Repurposing for Ubiquitin Chain Assembly. Mol.Cell, 56, 2014
|
|
2EKE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2eke by Molmil](/molmil-images/mine/2eke) | |
4KBL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4kbl by Molmil](/molmil-images/mine/4kbl) | Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an Ariadne-family E3 and insights into ligation mechanism | Descriptor: | E3 ubiquitin-protein ligase ARIH1, ZINC ION | Authors: | Duda, D.M, Olszewski, J.L, Schulman, B.A. | Deposit date: | 2013-04-23 | Release date: | 2013-05-29 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation Mechanism. Structure, 21, 2013
|
|
4LCD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4lcd by Molmil](/molmil-images/mine/4lcd) | |