8EBM

Structure of KLHDC2 substrate binding domain bound to KLHDC2's C-degron mimic

Summary for 8EBM

Entry DOI	10.2210/pdb8ebm/pdb
Descriptor	Kelch domain-containing protein 2, ASN-GLN-ARG-PHE-GLY-SER-ASN-ASN-THR-SER-GLY-SER (3 entities in total)
Functional Keywords	e3 ligase, ligase
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	82067.37
Authors	Scott, D.C.,Schulman, B.A. (deposition date: 2022-08-31, release date: 2023-02-22, Last modification date: 2023-10-25)
Primary citation	Scott, D.C.,King, M.T.,Baek, K.,Gee, C.T.,Kalathur, R.,Li, J.,Purser, N.,Nourse, A.,Chai, S.C.,Vaithiyalingam, S.,Chen, T.,Lee, R.E.,Elledge, S.J.,Kleiger, G.,Schulman, B.A. E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity. Mol.Cell, 83:770-786.e9, 2023 Cited by PubMed: 36805027 DOI: 10.1016/j.molcel.2023.01.019 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.58 Å)

Structure validation