8PDA

cryo-EM structure of Doa10 with RING domain in MSP1E3D1

Summary for 8PDA

• Entry DOI: 10.2210/pdb8pda/pdb
• EMDB information: 17608
• Descriptor: ERAD-associated E3 ubiquitin-protein ligase DOA10, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE (3 entities in total)
• Functional Keywords: erad, doa10, march6, teb4, retrotranslocation, ubiquitination, ubc6, sybody, sqle, squalenemonooxygenase, ligase
• Biological source: Saccharomyces cerevisiae (baker's yeast)
• Total number of polymer chains: 1
• Total formula weight: 154617.36

Authors

Botsch, J.J.,Braeuning, B.,Schulman, B.A. (deposition date: 2023-06-12, release date: 2024-01-17)

• Primary citation: Botsch, J.J.,Junker, R.,Sorgenfrei, M.,Ogger, P.P.,Stier, L.,von Gronau, S.,Murray, P.J.,Seeger, M.A.,Schulman, B.A.,Brauning, B.; Doa10/MARCH6 architecture interconnects E3 ligase activity with lipid-binding transmembrane channel to regulate SQLE.; Nat Commun, 15:410-410, 2024; PubMed: 38195637; DOI: 10.1038/s41467-023-44670-5

Experimental method

ELECTRON MICROSCOPY (3.58 Å)