8PDA

cryo-EM structure of Doa10 with RING domain in MSP1E3D1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000837	cellular_component	Doa10p ubiquitin ligase complex
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0005515	molecular_function	protein binding
A	0005635	cellular_component	nuclear envelope
A	0005637	cellular_component	nuclear inner membrane
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0008270	molecular_function	zinc ion binding
A	0016020	cellular_component	membrane
A	0016567	biological_process	protein ubiquitination
A	0016740	molecular_function	transferase activity
A	0030970	biological_process	retrograde protein transport, ER to cytosol
A	0036503	biological_process	ERAD pathway
A	0046872	molecular_function	metal ion binding
A	0061630	molecular_function	ubiquitin protein ligase activity

Functional Information from PROSITE/UniProt

site_id	PS01159
Number of Residues	25
Details	WW_DOMAIN_1 WW/rsp5/WWP domain signature. Wkfntilltl..YFtkrilesSSYVKP

Chain	Residue	Details
A	TRP781-PRO805

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	279
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	29
Details	Topological domain: {"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	57
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	69
Details	Zinc finger: {"description":"RING-CH-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00623","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00623","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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