8OIF

Structure of the UBE1L activating enzyme bound to ISG15 and UBE2L6

Summary for 8OIF

• Entry DOI: 10.2210/pdb8oif/pdb
• EMDB information: 16891
• Descriptor: Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, Ubiquitin/ISG15-conjugating enzyme E2 L6, ... (4 entities in total)
• Functional Keywords: ubiquitin-like, isg15, interferon-stimulated genes, antiviral, antiviral protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 147373.81

Authors

Wallace, I.,Kheewoong, B.,Prabu, J.R.,Vollrath, R.,von Gronau, S.,Schulman, B.A.,Swatek, K.N. (deposition date: 2023-03-22, release date: 2023-12-13)

• Primary citation: Wallace, I.,Baek, K.,Prabu, J.R.,Vollrath, R.,von Gronau, S.,Schulman, B.A.,Swatek, K.N.; Insights into the ISG15 transfer cascade by the UBE1L activating enzyme.; Nat Commun, 14:7970-7970, 2023; PubMed: 38042859; DOI: 10.1038/s41467-023-43711-3

Experimental method

ELECTRON MICROSCOPY (3.5 Å)