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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8OIF

Structure of the UBE1L activating enzyme bound to ISG15 and UBE2L6

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0004842molecular_functionubiquitin-protein transferase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006974biological_processDNA damage response
A0008641molecular_functionubiquitin-like modifier activating enzyme activity
A0016567biological_processprotein ubiquitination
A0016874molecular_functionligase activity
A0019782molecular_functionISG15 activating enzyme activity
A0032020biological_processISG15-protein conjugation
A0036211biological_processprotein modification process
A0045087biological_processinnate immune response
I0002376biological_processimmune system process
I0002682biological_processregulation of immune system process
I0003735molecular_functionstructural constituent of ribosome
I0005178molecular_functionintegrin binding
I0005515molecular_functionprotein binding
I0005576cellular_componentextracellular region
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0007229biological_processintegrin-mediated signaling pathway
I0009615biological_processresponse to virus
I0019941biological_processmodification-dependent protein catabolic process
I0022626cellular_componentcytosolic ribosome
I0030501biological_processpositive regulation of bone mineralization
I0031386molecular_functionprotein tag activity
I0031397biological_processnegative regulation of protein ubiquitination
I0032020biological_processISG15-protein conjugation
I0032461biological_processpositive regulation of protein oligomerization
I0032649biological_processregulation of type II interferon production
I0032728biological_processpositive regulation of interferon-beta production
I0032729biological_processpositive regulation of type II interferon production
I0032733biological_processpositive regulation of interleukin-10 production
I0034340biological_processresponse to type I interferon
I0042742biological_processdefense response to bacterium
I0045071biological_processnegative regulation of viral genome replication
I0045087biological_processinnate immune response
I0045648biological_processpositive regulation of erythrocyte differentiation
I0051240biological_processpositive regulation of multicellular organismal process
I0051607biological_processdefense response to virus
I0060339biological_processnegative regulation of type I interferon-mediated signaling pathway
I0070585biological_processprotein localization to mitochondrion
L0000209biological_processprotein polyubiquitination
L0004842molecular_functionubiquitin-protein transferase activity
L0005515molecular_functionprotein binding
L0005634cellular_componentnucleus
L0005654cellular_componentnucleoplasm
L0005737cellular_componentcytoplasm
L0005829cellular_componentcytosol
L0006511biological_processubiquitin-dependent protein catabolic process
L0016567biological_processprotein ubiquitination
L0016740molecular_functiontransferase activity
L0019787molecular_functionubiquitin-like protein transferase activity
L0032020biological_processISG15-protein conjugation
L0032446biological_processprotein modification by small protein conjugation
L0036211biological_processprotein modification process
L0042296molecular_functionISG15 transferase activity
L0043130molecular_functionubiquitin binding
L0045087biological_processinnate immune response
L0061631molecular_functionubiquitin conjugating enzyme activity
Functional Information from PROSITE/UniProt
site_idPS00183
Number of Residues16
DetailsUBC_1 Ubiquitin-conjugating (UBC) active site signature. YHPNVden.GqICLpiI
ChainResidueDetails
LTYR75-ILE90
site_idPS00865
Number of Residues9
DetailsUBIQUITIN_ACTIVAT_2 Ubiquitin-activating enzyme active site. PVCTVRyFP
ChainResidueDetails
APRO597-PRO605
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues152
DetailsRepeat: {"description":"1-2"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues1
DetailsActive site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU10132","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues29
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues78
DetailsDomain: {"description":"Ubiquitin-like 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues4
DetailsRegion: {"description":"Involved in the ligation of specific target proteins","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues5
DetailsMotif: {"description":"LRLRGG"}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues1
DetailsSite: {"description":"Interacts with activating enzyme","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues147
DetailsDomain: {"description":"UBC core","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues1
DetailsActive site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10133","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

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PDB entries from 2026-01-28

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