1TT5

Structure of APPBP1-UBA3-Ubc12N26: a unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8

Summary for 1TT5

Descriptoramyloid protein-binding protein 1, ubiquitin-activating enzyme E1C isoform 1, Ubiquitin-conjugating enzyme E2 M, ... (5 entities in total)
Functional Keywordscell cycle, ligase
Biological sourceHomo sapiens (human)
Total number of polymer chains6
Total molecular weight223428.73
Authors
Huang, D.T.,Miller, D.W.,Mathew, R.,Cassell, R.,Holton, J.M.,Roussel, M.F.,Schulman, B.A. (deposition date: 2004-06-21, release date: 2004-09-14, Last modification date: 2011-07-13)
Primary citation
Huang, D.T.,Miller, D.W.,Mathew, R.,Cassell, R.,Holton, J.M.,Roussel, M.F.,Schulman, B.A.
A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8.
Nat.Struct.Mol.Biol., 11:927-935, 2004
PubMed: 15361859 (PDB entries with the same primary citation)
DOI: 10.1038/nsmb826
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.6 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.238312.8%4.7%9.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 1tt5
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Molmil generated image of 1tt5
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Molmil generated image of 1tt5
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More Biological unit images

Molmil generated image of 1tt5
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Molmil generated image of 1tt5
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Molmil generated image of 1tt5
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (1tt5.pdb1.gz [156.56 KB])
Coordinate files for Biological unit (1tt5.pdb2.gz [145.13 KB])