4LYA
| EssC (ATPases 2 and 3) from Geobacillus thermodenitrificans (SeMet) | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Uncharacterized protein | 著者 | Dovala, D.L, Bendebury, A, Cox, J.S, Stroud, R.M, Rosenberg, O.S. | 登録日 | 2013-07-30 | 公開日 | 2015-02-04 | 最終更新日 | 2016-09-21 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Substrates Control Multimerization and Activation of the Multi-Domain ATPase Motor of Type VII Secretion. Cell(Cambridge,Mass.), 161, 2015
|
|
7OSK
| Ignisphaera aggregans GH53 catalytic domain | 分子名称: | Arabinogalactan endo-1,4-beta-galactosidase, CALCIUM ION, CHLORIDE ION, ... | 著者 | Fredslund, F, Lo Leggio, L, Poulsen, J.C, Rasmussen, K.K, Muderspach, S, Krogh, K.B.R.M, Jensen, K. | 登録日 | 2021-06-08 | 公開日 | 2021-09-29 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Engineering the substrate binding site of the hyperthermostable archaeal endo-beta-1,4-galactanase from Ignisphaera aggregans. Biotechnol Biofuels, 14, 2021
|
|
4NCY
| In situ trypsin crystallized on a MiTeGen micromesh with imidazole ligand | 分子名称: | 1,2-ETHANEDIOL, BENZAMIDINE, CALCIUM ION, ... | 著者 | Yin, X, Scalia, A, Leroy, L, Cuttitta, C.M, Polizzo, G.M, Ericson, D.L, Roessler, C.G, Campos, O, Agarwal, R, Allaire, M, Orville, A.M, Jackimowicz, R, Ma, M.Y, Sweet, R.M, Soares, A.S. | 登録日 | 2013-10-25 | 公開日 | 2014-04-09 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | 主引用文献 | Hitting the target: fragment screening with acoustic in situ co-crystallization of proteins plus fragment libraries on pin-mounted data-collection micromeshes. Acta Crystallogr.,Sect.D, 70, 2014
|
|
4MAO
| RSK2 T493M C-Terminal Kinase Domain in Complex with RMM58 | 分子名称: | (2Z)-2-(1H-1,2,4-triazol-1-yl)-3-[3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl]prop-2-enenitrile, Ribosomal protein S6 kinase alpha-3, SODIUM ION | 著者 | Miller, R.M, Taunton, J. | 登録日 | 2013-08-16 | 公開日 | 2014-10-22 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Design of reversible, cysteine-targeted Michael acceptors guided by kinetic and computational analysis. J.Am.Chem.Soc., 136, 2014
|
|
4LXJ
| Saccharomyces cerevisiae lanosterol 14-alpha demethylase with lanosterol bound | 分子名称: | LANOSTEROL, Lanosterol 14-alpha demethylase, OXYGEN MOLECULE, ... | 著者 | Monk, B.C, Tomasiak, T.M, Keniya, M.V, Huschmann, F.U, Tyndall, J.D.A, O'Connell III, J.D, Cannon, R.D, McDonald, J, Rodriguez, A, Finer-Moore, J, Stroud, R.M. | 登録日 | 2013-07-29 | 公開日 | 2014-01-29 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer. Proc.Natl.Acad.Sci.USA, 111, 2014
|
|
7OPQ
| Rab27a fusion with Slp2a-RBDa1 effector covalent adduct with CA1 in C188 | 分子名称: | 1-[(2~{S})-2-(4-methoxyphenyl)pyrrolidin-1-yl]propan-1-one, GLYCEROL, MAGNESIUM ION, ... | 著者 | Jamshidiha, M, Tersa, M, Lanyon-Hogg, T, Perez-Dorado, I, Sutherell, C.L, De Vita, E, Morgan, R.M.L, Tate, E.W, Cota, E. | 登録日 | 2021-06-01 | 公開日 | 2022-04-06 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | 主引用文献 | Identification of the first structurally validated covalent ligands of the small GTPase RAB27A. Rsc Med Chem, 13, 2022
|
|
7OPR
| Rab27a fusion with Slp2a-RBDa1 effector covalent adduct with CB1 in C123 | 分子名称: | GLYCEROL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | 著者 | Jamshidiha, M, Tersa, M, Lanyon-Hogg, T, Perez-Dorado, I, Sutherell, C.L, De Vita, E, Morgan, R.M.L, Tate, E.W, Cota, E. | 登録日 | 2021-06-01 | 公開日 | 2022-04-06 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | 主引用文献 | Identification of the first structurally validated covalent ligands of the small GTPase RAB27A. Rsc Med Chem, 13, 2022
|
|
7OPP
| Crystal structure of the Rab27a fusion with Slp2a-RBDa1 effector for SF4 pocket drug targeting | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Synaptotagmin-like protein 2,Ras-related protein Rab-27A | 著者 | Jamshidiha, M, Tersa, M, Lanyon-Hogg, T, Perez-Dorado, I, Sutherell, C.L, De Vita, E, Morgan, R.M.L, Tate, E.W, Cota, E. | 登録日 | 2021-06-01 | 公開日 | 2022-04-06 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | 主引用文献 | Identification of the first structurally validated covalent ligands of the small GTPase RAB27A. Rsc Med Chem, 13, 2022
|
|
4M55
| Crystal structure of Human UDP-xylose synthase R236H substitution | 分子名称: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PYROPHOSPHATE 2-, SULFATE ION, ... | 著者 | Walsh Jr, R.M, Polizzi, S.J, Wood, Z.A. | 登録日 | 2013-08-08 | 公開日 | 2013-08-28 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.86 Å) | 主引用文献 | Man o' war mutation in UDP-alpha-D-xylose synthase favors the abortive catalytic cycle and uncovers a latent potential for hexamer formation. Biochemistry, 54, 2015
|
|
4NJG
| Crystal Structure of QueE from Burkholderia multivorans in complex with AdoMet and 6-carboxypterin | 分子名称: | 6-CARBOXYPTERIN, 7-carboxy-7-deazaguanine synthase, IRON/SULFUR CLUSTER, ... | 著者 | Dowling, D.P, Bruender, N.A, Young, A.P, McCarty, R.M, Bandarian, V, Drennan, C.L. | 登録日 | 2013-11-10 | 公開日 | 2013-12-25 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.598 Å) | 主引用文献 | Radical SAM enzyme QueE defines a new minimal core fold and metal-dependent mechanism. Nat.Chem.Biol., 10, 2014
|
|
4OO9
| Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator mavoglurant | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Mavoglurant, Metabotropic glutamate receptor 5, ... | 著者 | Dore, A.S, Okrasa, K, Patel, J.C, Serrano-Vega, M, Bennett, K, Cooke, R.M, Errey, J.C, Jazayeri, A, Khan, S, Tehan, B, Weir, M, Wiggin, G.R, Marshall, F.H. | 登録日 | 2014-01-31 | 公開日 | 2014-07-02 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain. Nature, 511, 2014
|
|
4OX5
| Structure of the LdcB LD-carboxypeptidase reveals the molecular basis of peptidoglycan recognition | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... | 著者 | Hoyland, C.N, Aldridge, C, Cleverley, R.M, Sidiq, K, Duchene, M.C, Daniel, R.A, Vollmer, W, Lewis, R.J. | 登録日 | 2014-02-04 | 公開日 | 2014-05-21 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structure of the LdcB LD-carboxypeptidase reveals the molecular basis of peptidoglycan recognition. Structure, 22, 2014
|
|
4OXD
| Structure of the LdcB LD-carboxypeptidase reveals the molecular basis of peptidoglycan recognition | 分子名称: | CHLORIDE ION, LYSINE, LdcB LD-carboxypeptidase, ... | 著者 | Hoyland, C.N, Aldridge, C, Cleverley, R.M, Sidiq, K, Duchene, M.C, Daniel, R.A, Vollmer, W, Lewis, R.J. | 登録日 | 2014-02-05 | 公開日 | 2014-05-21 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure of the LdcB LD-carboxypeptidase reveals the molecular basis of peptidoglycan recognition. Structure, 22, 2014
|
|
4OAA
| Crystal structure of E. coli lactose permease G46W,G262W bound to sugar | 分子名称: | Lactose/galactose transporter, beta-D-galactopyranose-(1-1)-1-thio-beta-D-galactopyranose | 著者 | Kumar, H, Kasho, V, Smirnova, I, Finer-Moore, J, Kaback, H.R, Stroud, R.M. | 登録日 | 2014-01-03 | 公開日 | 2014-01-29 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Structure of sugar-bound LacY. Proc.Natl.Acad.Sci.USA, 111, 2014
|
|
4N1A
| Thermomonospora curvata EccC (ATPases 2 and 3) in complex with a signal sequence peptide | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cell divisionFtsK/SpoIIIE, MAGNESIUM ION, ... | 著者 | Dovala, D.L, Bendebury, A, Cox, J.S, Stroud, R.M, Rosenberg, O.S. | 登録日 | 2013-10-03 | 公開日 | 2015-02-11 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.24 Å) | 主引用文献 | Substrates Control Multimerization and Activation of the Multi-Domain ATPase Motor of Type VII Secretion. Cell(Cambridge,Mass.), 161, 2015
|
|
4N8Z
| In situ lysozyme crystallized on a MiTeGen micromesh with benzamidine ligand | 分子名称: | BENZAMIDINE, CHLORIDE ION, Lysozyme C, ... | 著者 | Yin, X, Scalia, A, Leroy, L, Cuttitta, C.M, Polizzo, G.M, Ericson, D.L, Roessler, C.G, Campos, O, Agarwal, R, Allaire, M, Orville, A.M, Jackimowicz, R, Ma, M.Y, Sweet, R.M, Soares, A.S. | 登録日 | 2013-10-18 | 公開日 | 2013-10-30 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Hitting the target: fragment screening with acoustic in situ co-crystallization of proteins plus fragment libraries on pin-mounted data-collection micromeshes. Acta Crystallogr.,Sect.D, 70, 2014
|
|
4MP2
| Crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor PA1 | 分子名称: | (5-bromo-2,4-dihydroxyphenyl)(1,3-dihydro-2H-isoindol-2-yl)methanone, L(+)-TARTARIC ACID, [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, ... | 著者 | Gui, W.J, Tso, S.C, Chuang, J.L, Wu, C.Y, Qi, X, Tambar, U.K, Wynn, R.M, Chuang, D.T. | 登録日 | 2013-09-12 | 公開日 | 2014-01-01 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.751 Å) | 主引用文献 | Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket. J.Biol.Chem., 289, 2014
|
|
4O2A
| Tubulin-BAL27862 complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-[(4-{1-[2-(4-aminophenyl)-2-oxoethyl]-1H-benzimidazol-2-yl}-1,2,5-oxadiazol-3-yl)amino]propanenitrile, ADENOSINE-5'-DIPHOSPHATE, ... | 著者 | Prota, A.E, Franck, D, Bachmann, F, Bargsten, K, Buey, R.M, Pohlmann, J, Reinelt, S, Lane, H, Steinmetz, M.O. | 登録日 | 2013-12-17 | 公開日 | 2014-03-05 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | The Novel Microtubule-Destabilizing Drug BAL27862 Binds to the Colchicine Site of Tubulin with Distinct Effects on Microtubule Organization. J.Mol.Biol., 426, 2014
|
|
7Q2U
| The crystal structure of the HINT1 Q62A mutant. | 分子名称: | CACODYLATE ION, HEXAETHYLENE GLYCOL, Histidine triad nucleotide-binding protein 1, ... | 著者 | Dolot, R.M, Strom, A.M, Wagner, C.R. | 登録日 | 2021-10-26 | 公開日 | 2021-11-03 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | 主引用文献 | Dynamic Long-Range Interactions Influence Substrate Binding and Catalysis by Human Histidine Triad Nucleotide-Binding Proteins (HINTs), Key Regulators of Multiple Cellular Processes and Activators of Antiviral ProTides. Biochemistry, 61, 2022
|
|
4O1Z
| Crystal Structure of Ovine Cyclooxygenase-1 Complex with Meloxicam | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-hydroxy-2-methyl-N-(5-methyl-1,3-thiazol-2-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide, ... | 著者 | Xu, S, Hermanson, D.J, Banerjee, S, Ghebreselasie, K, Clayton, G.M, Garavito, R.M, Marnett, L.J. | 登録日 | 2013-12-16 | 公開日 | 2014-01-22 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Oxicams Bind in a Novel Mode to the Cyclooxygenase Active Site via a Two-water-mediated H-bonding Network. J.Biol.Chem., 289, 2014
|
|
4O2B
| Tubulin-Colchicine complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Prota, A.E, Franck, D, Bachmann, F, Bargsten, K, Buey, R.M, Pohlmann, J, Reinelt, S, Lane, H, Steinmetz, M.O. | 登録日 | 2013-12-17 | 公開日 | 2014-03-05 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | The Novel Microtubule-Destabilizing Drug BAL27862 Binds to the Colchicine Site of Tubulin with Distinct Effects on Microtubule Organization. J.Mol.Biol., 426, 2014
|
|
4M9E
| Structure of Klf4 zinc finger DNA binding domain in complex with methylated DNA | 分子名称: | ACETATE ION, DNA (5'-D(*GP*AP*GP*GP*(5CM)P*GP*TP*GP*GP*C)-3'), DNA (5'-D(*GP*CP*CP*AP*(5CM)P*GP*CP*CP*TP*C)-3'), ... | 著者 | Liu, Y, Olanrewaju, Y.O, Blumenthal, R.M, Zhang, X, Cheng, X. | 登録日 | 2013-08-14 | 公開日 | 2014-02-12 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.851 Å) | 主引用文献 | Structural basis for Klf4 recognition of methylated DNA. Nucleic Acids Res., 42, 2014
|
|
4OX3
| Structure of the LdcB LD-carboxypeptidase reveals the molecular basis of peptidoglycan recognition | 分子名称: | PHOSPHATE ION, Putative carboxypeptidase YodJ, ZINC ION | 著者 | Hoyland, C.N, Aldridge, C, Cleverley, R.M, Sidiq, K, Duchene, M.C, Daniel, R.A, Vollmer, W, Lewis, R.J. | 登録日 | 2014-02-04 | 公開日 | 2014-06-11 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of the LdcB LD-carboxypeptidase reveals the molecular basis of peptidoglycan recognition. Structure, 22, 2014
|
|
4MP7
| Crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor PA7 | 分子名称: | 4-(1,3-dihydro-2H-isoindol-2-ylcarbonyl)benzene-1,3-diol, L(+)-TARTARIC ACID, [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, ... | 著者 | Gui, W.J, Tso, S.C, Chuang, J.L, Wu, C.Y, Qi, X, Tambar, U.K, Wynn, R.M, Chuang, D.T. | 登録日 | 2013-09-12 | 公開日 | 2014-01-01 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket. J.Biol.Chem., 289, 2014
|
|
4MPE
| Crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor PS8 | 分子名称: | 4-[(5-hydroxy-1,3-dihydro-2H-isoindol-2-yl)sulfonyl]benzene-1,3-diol, L(+)-TARTARIC ACID, [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, ... | 著者 | Gui, W.J, Tso, S.C, Chuang, J.L, Wu, C.Y, Qi, X, Tambar, U.K, Wynn, R.M, Chuang, D.T. | 登録日 | 2013-09-12 | 公開日 | 2014-01-01 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.953 Å) | 主引用文献 | Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket. J.Biol.Chem., 289, 2014
|
|