7Q2U

The crystal structure of the HINT1 Q62A mutant.

This is a non-PDB format compatible entry.

Summary for 7Q2U

• Entry DOI: 10.2210/pdb7q2u/pdb
• Descriptor: Histidine triad nucleotide-binding protein 1, HEXAETHYLENE GLYCOL, CACODYLATE ION, ... (5 entities in total)
• Functional Keywords: histidine triad nucleotide-binding protein, hint, hit family, q62a mutant, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 55818.05

Authors

Dolot, R.M.,Strom, A.M.,Wagner, C.R. (deposition date: 2021-10-26, release date: 2021-11-03, Last modification date: 2024-02-07)

• Primary citation: Strom, A.,Shah, R.,Dolot, R.,Rogers, M.S.,Tong, C.L.,Wang, D.,Xia, Y.,Lipscomb, J.D.,Wagner, C.R.; Dynamic Long-Range Interactions Influence Substrate Binding and Catalysis by Human Histidine Triad Nucleotide-Binding Proteins (HINTs), Key Regulators of Multiple Cellular Processes and Activators of Antiviral ProTides.; Biochemistry, 61:2648-2661, 2022; PubMed: 36398895; DOI: 10.1021/acs.biochem.2c00506

Experimental method

X-RAY DIFFRACTION (2.27 Å)