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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7Q2U

The crystal structure of the HINT1 Q62A mutant.

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
AAA0000118cellular_componenthistone deacetylase complex
AAA0000166molecular_functionnucleotide binding
AAA0003824molecular_functioncatalytic activity
AAA0005080molecular_functionprotein kinase C binding
AAA0005515molecular_functionprotein binding
AAA0005634cellular_componentnucleus
AAA0005654cellular_componentnucleoplasm
AAA0005737cellular_componentcytoplasm
AAA0005829cellular_componentcytosol
AAA0005856cellular_componentcytoskeleton
AAA0006351biological_processDNA-templated transcription
AAA0006355biological_processregulation of DNA-templated transcription
AAA0006508biological_processproteolysis
AAA0006915biological_processapoptotic process
AAA0007165biological_processsignal transduction
AAA0008233molecular_functionpeptidase activity
AAA0008234molecular_functioncysteine-type peptidase activity
AAA0009154biological_processpurine ribonucleotide catabolic process
AAA0016787molecular_functionhydrolase activity
AAA0016926biological_processprotein desumoylation
AAA0016929molecular_functiondeSUMOylase activity
AAA0043530molecular_functionadenosine 5'-monophosphoramidase activity
AAA0050850biological_processpositive regulation of calcium-mediated signaling
AAA0070062cellular_componentextracellular exosome
AAA0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
BBB0000118cellular_componenthistone deacetylase complex
BBB0000166molecular_functionnucleotide binding
BBB0003824molecular_functioncatalytic activity
BBB0005080molecular_functionprotein kinase C binding
BBB0005515molecular_functionprotein binding
BBB0005634cellular_componentnucleus
BBB0005654cellular_componentnucleoplasm
BBB0005737cellular_componentcytoplasm
BBB0005829cellular_componentcytosol
BBB0005856cellular_componentcytoskeleton
BBB0006351biological_processDNA-templated transcription
BBB0006355biological_processregulation of DNA-templated transcription
BBB0006508biological_processproteolysis
BBB0006915biological_processapoptotic process
BBB0007165biological_processsignal transduction
BBB0008233molecular_functionpeptidase activity
BBB0008234molecular_functioncysteine-type peptidase activity
BBB0009154biological_processpurine ribonucleotide catabolic process
BBB0016787molecular_functionhydrolase activity
BBB0016926biological_processprotein desumoylation
BBB0016929molecular_functiondeSUMOylase activity
BBB0043530molecular_functionadenosine 5'-monophosphoramidase activity
BBB0050850biological_processpositive regulation of calcium-mediated signaling
BBB0070062cellular_componentextracellular exosome
BBB0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
CCC0000118cellular_componenthistone deacetylase complex
CCC0000166molecular_functionnucleotide binding
CCC0003824molecular_functioncatalytic activity
CCC0005080molecular_functionprotein kinase C binding
CCC0005515molecular_functionprotein binding
CCC0005634cellular_componentnucleus
CCC0005654cellular_componentnucleoplasm
CCC0005737cellular_componentcytoplasm
CCC0005829cellular_componentcytosol
CCC0005856cellular_componentcytoskeleton
CCC0006351biological_processDNA-templated transcription
CCC0006355biological_processregulation of DNA-templated transcription
CCC0006508biological_processproteolysis
CCC0006915biological_processapoptotic process
CCC0007165biological_processsignal transduction
CCC0008233molecular_functionpeptidase activity
CCC0008234molecular_functioncysteine-type peptidase activity
CCC0009154biological_processpurine ribonucleotide catabolic process
CCC0016787molecular_functionhydrolase activity
CCC0016926biological_processprotein desumoylation
CCC0016929molecular_functiondeSUMOylase activity
CCC0043530molecular_functionadenosine 5'-monophosphoramidase activity
CCC0050850biological_processpositive regulation of calcium-mediated signaling
CCC0070062cellular_componentextracellular exosome
CCC0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
DDD0000118cellular_componenthistone deacetylase complex
DDD0000166molecular_functionnucleotide binding
DDD0003824molecular_functioncatalytic activity
DDD0005080molecular_functionprotein kinase C binding
DDD0005515molecular_functionprotein binding
DDD0005634cellular_componentnucleus
DDD0005654cellular_componentnucleoplasm
DDD0005737cellular_componentcytoplasm
DDD0005829cellular_componentcytosol
DDD0005856cellular_componentcytoskeleton
DDD0006351biological_processDNA-templated transcription
DDD0006355biological_processregulation of DNA-templated transcription
DDD0006508biological_processproteolysis
DDD0006915biological_processapoptotic process
DDD0007165biological_processsignal transduction
DDD0008233molecular_functionpeptidase activity
DDD0008234molecular_functioncysteine-type peptidase activity
DDD0009154biological_processpurine ribonucleotide catabolic process
DDD0016787molecular_functionhydrolase activity
DDD0016926biological_processprotein desumoylation
DDD0016929molecular_functiondeSUMOylase activity
DDD0043530molecular_functionadenosine 5'-monophosphoramidase activity
DDD0050850biological_processpositive regulation of calcium-mediated signaling
DDD0070062cellular_componentextracellular exosome
DDD0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
Functional Information from PROSITE/UniProt
site_idPS00892
Number of Residues19
DetailsHIT_1 HIT domain signature. NegsdGgQsVyHVHLHVLG
ChainResidueDetails
AAAASN99-GLY117
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues432
DetailsDomain: {"description":"HIT","evidences":[{"source":"PROSITE-ProRule","id":"PRU00464","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues16
DetailsMotif: {"description":"Histidine triad motif"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues4
DetailsActive site: {"description":"Tele-AMP-histidine intermediate","evidences":[{"source":"PubMed","id":"9323207","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues24
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"22869114","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3TW2","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues8
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues8
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P70349","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

248335

PDB entries from 2026-01-28

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