Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7Q2U

The crystal structure of the HINT1 Q62A mutant.

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0000118	cellular_component	histone deacetylase complex
AAA	0000166	molecular_function	nucleotide binding
AAA	0003824	molecular_function	catalytic activity
AAA	0005080	molecular_function	protein kinase C binding
AAA	0005515	molecular_function	protein binding
AAA	0005634	cellular_component	nucleus
AAA	0005654	cellular_component	nucleoplasm
AAA	0005737	cellular_component	cytoplasm
AAA	0005829	cellular_component	cytosol
AAA	0005856	cellular_component	cytoskeleton
AAA	0005886	cellular_component	plasma membrane
AAA	0006355	biological_process	regulation of DNA-templated transcription
AAA	0006508	biological_process	proteolysis
AAA	0006915	biological_process	apoptotic process
AAA	0007165	biological_process	signal transduction
AAA	0008234	molecular_function	cysteine-type peptidase activity
AAA	0009154	biological_process	purine ribonucleotide catabolic process
AAA	0016787	molecular_function	hydrolase activity
AAA	0016926	biological_process	protein desumoylation
AAA	0016929	molecular_function	deSUMOylase activity
AAA	0043530	molecular_function	adenosine 5'-monophosphoramidase activity
AAA	0050850	biological_process	positive regulation of calcium-mediated signaling
AAA	0070062	cellular_component	extracellular exosome
AAA	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator
BBB	0000118	cellular_component	histone deacetylase complex
BBB	0000166	molecular_function	nucleotide binding
BBB	0003824	molecular_function	catalytic activity
BBB	0005080	molecular_function	protein kinase C binding
BBB	0005515	molecular_function	protein binding
BBB	0005634	cellular_component	nucleus
BBB	0005654	cellular_component	nucleoplasm
BBB	0005737	cellular_component	cytoplasm
BBB	0005829	cellular_component	cytosol
BBB	0005856	cellular_component	cytoskeleton
BBB	0005886	cellular_component	plasma membrane
BBB	0006355	biological_process	regulation of DNA-templated transcription
BBB	0006508	biological_process	proteolysis
BBB	0006915	biological_process	apoptotic process
BBB	0007165	biological_process	signal transduction
BBB	0008234	molecular_function	cysteine-type peptidase activity
BBB	0009154	biological_process	purine ribonucleotide catabolic process
BBB	0016787	molecular_function	hydrolase activity
BBB	0016926	biological_process	protein desumoylation
BBB	0016929	molecular_function	deSUMOylase activity
BBB	0043530	molecular_function	adenosine 5'-monophosphoramidase activity
BBB	0050850	biological_process	positive regulation of calcium-mediated signaling
BBB	0070062	cellular_component	extracellular exosome
BBB	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator
CCC	0000118	cellular_component	histone deacetylase complex
CCC	0000166	molecular_function	nucleotide binding
CCC	0003824	molecular_function	catalytic activity
CCC	0005080	molecular_function	protein kinase C binding
CCC	0005515	molecular_function	protein binding
CCC	0005634	cellular_component	nucleus
CCC	0005654	cellular_component	nucleoplasm
CCC	0005737	cellular_component	cytoplasm
CCC	0005829	cellular_component	cytosol
CCC	0005856	cellular_component	cytoskeleton
CCC	0005886	cellular_component	plasma membrane
CCC	0006355	biological_process	regulation of DNA-templated transcription
CCC	0006508	biological_process	proteolysis
CCC	0006915	biological_process	apoptotic process
CCC	0007165	biological_process	signal transduction
CCC	0008234	molecular_function	cysteine-type peptidase activity
CCC	0009154	biological_process	purine ribonucleotide catabolic process
CCC	0016787	molecular_function	hydrolase activity
CCC	0016926	biological_process	protein desumoylation
CCC	0016929	molecular_function	deSUMOylase activity
CCC	0043530	molecular_function	adenosine 5'-monophosphoramidase activity
CCC	0050850	biological_process	positive regulation of calcium-mediated signaling
CCC	0070062	cellular_component	extracellular exosome
CCC	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator
DDD	0000118	cellular_component	histone deacetylase complex
DDD	0000166	molecular_function	nucleotide binding
DDD	0003824	molecular_function	catalytic activity
DDD	0005080	molecular_function	protein kinase C binding
DDD	0005515	molecular_function	protein binding
DDD	0005634	cellular_component	nucleus
DDD	0005654	cellular_component	nucleoplasm
DDD	0005737	cellular_component	cytoplasm
DDD	0005829	cellular_component	cytosol
DDD	0005856	cellular_component	cytoskeleton
DDD	0005886	cellular_component	plasma membrane
DDD	0006355	biological_process	regulation of DNA-templated transcription
DDD	0006508	biological_process	proteolysis
DDD	0006915	biological_process	apoptotic process
DDD	0007165	biological_process	signal transduction
DDD	0008234	molecular_function	cysteine-type peptidase activity
DDD	0009154	biological_process	purine ribonucleotide catabolic process
DDD	0016787	molecular_function	hydrolase activity
DDD	0016926	biological_process	protein desumoylation
DDD	0016929	molecular_function	deSUMOylase activity
DDD	0043530	molecular_function	adenosine 5'-monophosphoramidase activity
DDD	0050850	biological_process	positive regulation of calcium-mediated signaling
DDD	0070062	cellular_component	extracellular exosome
DDD	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator

Functional Information from PROSITE/UniProt

site_id	PS00892
Number of Residues	19
Details	HIT_1 HIT domain signature. NegsdGgQsVyHVHLHVLG

Chain	Residue	Details
AAA	ASN99-GLY117

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Tele-AMP-histidine intermediate => ECO:0000269\|PubMed:9323207

Chain	Residue	Details
AAA	HIS112
BBB	HIS112
CCC	HIS112
DDD	HIS112

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269\|PubMed:22869114, ECO:0007744\|PDB:3TW2

Chain	Residue	Details
AAA	ASP43
CCC	ASN99
CCC	GLY105
CCC	HIS112
DDD	ASP43
DDD	ASN99
DDD	GLY105
DDD	HIS112
AAA	ASN99
AAA	GLY105
AAA	HIS112
BBB	ASP43
BBB	ASN99
BBB	GLY105
BBB	HIS112
CCC	ASP43

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: N-acetylalanine => ECO:0007744\|PubMed:22814378

Chain	Residue	Details
AAA	ALA2
BBB	ALA2
CCC	ALA2
DDD	ALA2

site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
AAA	LYS21
AAA	LYS30
BBB	LYS21
BBB	LYS30
CCC	LYS21
CCC	LYS30
DDD	LYS21
DDD	LYS30

site_id	SWS_FT_FI5
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P70349

Chain	Residue	Details
AAA	SER45
AAA	SER72
BBB	SER45
BBB	SER72
CCC	SER45
CCC	SER72
DDD	SER45
DDD	SER72

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)