4O2A

Tubulin-BAL27862 complex

Summary for 4O2A

• Entry DOI: 10.2210/pdb4o2a/pdb
• Related: 4O2B
• Descriptor: Tubulin alpha-1B chain, IMIDAZOLE, GUANOSINE-5'-DIPHOSPHATE, ... (15 entities in total)
• Functional Keywords: alpha-tubulin, beta-tubulin, ligase, gtpase, microtubule, stathmin, bal27862, cell cycle, tubulin fold, cytoskeleton, cell cycle-inhibitor complex, cell cycle/inhibitor
• Biological source: Rattus norvegicus (rat); More
• Cellular location: Cytoplasm, cytoskeleton: P81947 Q6B856; Golgi apparatus : P63043
• Total number of polymer chains: 6
• Total formula weight: 265439.78

Authors

Prota, A.E.,Franck, D.,Bachmann, F.,Bargsten, K.,Buey, R.M.,Pohlmann, J.,Reinelt, S.,Lane, H.,Steinmetz, M.O. (deposition date: 2013-12-17, release date: 2014-03-05, Last modification date: 2023-09-20)

• Primary citation: Prota, A.E.,Danel, F.,Bachmann, F.,Bargsten, K.,Buey, R.M.,Pohlmann, J.,Reinelt, S.,Lane, H.,Steinmetz, M.O.; The Novel Microtubule-Destabilizing Drug BAL27862 Binds to the Colchicine Site of Tubulin with Distinct Effects on Microtubule Organization.; J.Mol.Biol., 426:1848-1860, 2014; PubMed: 24530796; DOI: 10.1016/j.jmb.2014.02.005

Experimental method

X-RAY DIFFRACTION (2.5 Å)