7OPQ

Rab27a fusion with Slp2a-RBDa1 effector covalent adduct with CA1 in C188

Summary for 7OPQ

Entry DOI	10.2210/pdb7opq/pdb
Descriptor	Synaptotagmin-like protein 2,Ras-related protein Rab-27A, 1-[(2~{S})-2-(4-methoxyphenyl)pyrrolidin-1-yl]propan-1-one, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (6 entities in total)
Functional Keywords	gtpase, acrylamide, cysteine-reactive, exocytosis
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	54010.69
Authors	Jamshidiha, M.,Tersa, M.,Lanyon-Hogg, T.,Perez-Dorado, I.,Sutherell, C.L.,De Vita, E.,Morgan, R.M.L.,Tate, E.W.,Cota, E. (deposition date: 2021-06-01, release date: 2022-04-06, Last modification date: 2024-01-31)
Primary citation	Jamshidiha, M.,Lanyon-Hogg, T.,Sutherell, C.L.,Craven, G.B.,Tersa, M.,De Vita, E.,Brustur, D.,Perez-Dorado, I.,Hassan, S.,Petracca, R.,Morgan, R.M.,Sanz-Hernandez, M.,Norman, J.C.,Armstrong, A.,Mann, D.J.,Cota, E.,Tate, E.W. Identification of the first structurally validated covalent ligands of the small GTPase RAB27A. Rsc Med Chem, 13:150-155, 2022 Cited by PubMed: 35308027 DOI: 10.1039/d1md00225b PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.23 Å)

Structure validation