7OPQ

Rab27a fusion with Slp2a-RBDa1 effector covalent adduct with CA1 in C188

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Synaptotagmin-like protein 2,Ras-related protein Rab-27A	polymer	229	25857.2	2	UniProt (Q9HCH5) UniProt (P51159) Pfam (PF02318) Pfam (PF00071)	Homo sapiens (Human)	Breast cancer-associated antigen SGA-72M,Exophilin-4,Rab-27,GTP-binding protein Ram
2	C, L (A, B)	1-[(2~{S})-2-(4-methoxyphenyl)pyrrolidin-1-yl]propan-1-one	non-polymer		233.3	2	Chemie (06D)	Homo sapiens
3	D, M (A, B)	PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER	non-polymer		522.2	2	Chemie (GNP)
4	E, N (A, B)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
5	F, G, H, I, J... (A, B)	GLYCEROL	non-polymer		92.1	8	Chemie (GOL)
6	Q, R (A, B)	water	water		18.0	179	Chemie (HOH)

Sequence modifications

A, B: -35 - -8 (UniProt: Q9HCH5)

PDB	External Database	Details
His -37	-	expression tag
Met -36	-	expression tag
Gly -7	-	linker
Ser -6	-	linker
Gly -5	-	linker
Ser -4	-	linker
Gly -3	-	linker
Ser -2	-	linker
Gly -1	-	linker

A, B: 0 - 191 (UniProt: P51159)

PDB	External Database	Details
Leu 77	Gln 78	engineered mutation
Ser 122	Cys 123	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	51714.3
Non-Polymers*	Number of molecules	14
	Total formula weight	2296.4
All*	Total formula weight	54010.7

*Water molecules are not included.