4M55

Crystal structure of Human UDP-xylose synthase R236H substitution

Summary for 4M55

• Entry DOI: 10.2210/pdb4m55/pdb
• Related: 4LK3
• Descriptor: UDP-glucuronic acid decarboxylase 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PYROPHOSPHATE 2-, ... (5 entities in total)
• Functional Keywords: short-chain dehydrogenase/reductase, decarboxylase, lyase, membrane, rossmann fold
• Biological source: Homo sapiens (human)
• Cellular location: Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein : Q8NBZ7
• Total number of polymer chains: 6
• Total formula weight: 232859.73

Authors

Walsh Jr., R.M.,Polizzi, S.J.,Wood, Z.A. (deposition date: 2013-08-08, release date: 2013-08-28, Last modification date: 2024-02-28)

• Primary citation: Walsh Jr., R.M.,Polizzi, S.J.,Kadirvelraj, R.,Howard, W.W.,Wood, Z.A.; Man o' war mutation in UDP-alpha-D-xylose synthase favors the abortive catalytic cycle and uncovers a latent potential for hexamer formation.; Biochemistry, 54:807-819, 2015; PubMed: 25521717; DOI: 10.1021/bi501357c

Experimental method

X-RAY DIFFRACTION (2.86 Å)