4O2B

Tubulin-Colchicine complex

Summary for 4O2B

Entry DOI	10.2210/pdb4o2b/pdb
Related	4O2A
Descriptor	Tubulin alpha-1B chain, N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (15 entities in total)
Functional Keywords	alpha-tubulin, beta-tubulin, ligase, gtpase, microtubule, stathmin, colchicine, cell cycle, tubulin fold, cytoskeleton, cell cycle-inhibitor complex, cell cycle/inhibitor
Biological source	Rattus norvegicus (rat) More
Cellular location	Cytoplasm, cytoskeleton: P81947 Cytoplasm, cytoskeleton (By similarity): Q6B856 Golgi apparatus: P63043
Total number of polymer chains	6
Total formula weight	266921.88
Authors	Prota, A.E.,Franck, D.,Bachmann, F.,Bargsten, K.,Buey, R.M.,Pohlmann, J.,Reinelt, S.,Lane, H.,Steinmetz, M.O. (deposition date: 2013-12-17, release date: 2014-03-05, Last modification date: 2023-09-20)
Primary citation	Prota, A.E.,Danel, F.,Bachmann, F.,Bargsten, K.,Buey, R.M.,Pohlmann, J.,Reinelt, S.,Lane, H.,Steinmetz, M.O. The Novel Microtubule-Destabilizing Drug BAL27862 Binds to the Colchicine Site of Tubulin with Distinct Effects on Microtubule Organization. J.Mol.Biol., 426:1848-1860, 2014 Cited by PubMed: 24530796 DOI: 10.1016/j.jmb.2014.02.005 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation