4MPE
Crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor PS8
Summary for 4MPE
Entry DOI | 10.2210/pdb4mpe/pdb |
Related | 4MP2 4MP7 4MPC |
Descriptor | [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial, 4-[(5-hydroxy-1,3-dihydro-2H-isoindol-2-yl)sulfonyl]benzene-1,3-diol, L(+)-TARTARIC ACID, ... (4 entities in total) |
Functional Keywords | ghkl protein kinase, pyruvate dehydrogenase complex, mitochondrial protein kinases, impaired glucose oxidation, hepatic steatosis, type 2 diabetes, cancer, bergerat nucleotide-binding fold, protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Mitochondrion matrix: Q15119 |
Total number of polymer chains | 1 |
Total formula weight | 45690.81 |
Authors | Gui, W.J.,Tso, S.C.,Chuang, J.L.,Wu, C.Y.,Qi, X.,Tambar, U.K.,Wynn, R.M.,Chuang, D.T. (deposition date: 2013-09-12, release date: 2014-01-01, Last modification date: 2024-02-28) |
Primary citation | Tso, S.C.,Qi, X.,Gui, W.J.,Wu, C.Y.,Chuang, J.L.,Wernstedt-Asterholm, I.,Morlock, L.K.,Owens, K.R.,Scherer, P.E.,Williams, N.S.,Tambar, U.K.,Wynn, R.M.,Chuang, D.T. Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket. J.Biol.Chem., 289:4432-4443, 2014 Cited by PubMed: 24356970DOI: 10.1074/jbc.M113.533885 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.953 Å) |
Structure validation
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