4MAO

RSK2 T493M C-Terminal Kinase Domain in Complex with RMM58

Summary for 4MAO

• Entry DOI: 10.2210/pdb4mao/pdb
• Related: 4M8T
• Descriptor: Ribosomal protein S6 kinase alpha-3, (2Z)-2-(1H-1,2,4-triazol-1-yl)-3-[3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl]prop-2-enenitrile, SODIUM ION, ... (4 entities in total)
• Functional Keywords: protein kinase, phosphorylation, covalent inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Mus musculus (mouse)
• Cellular location: Nucleus : P18654
• Total number of polymer chains: 1
• Total formula weight: 40523.04

Authors

Miller, R.M.,Taunton, J. (deposition date: 2013-08-16, release date: 2014-10-22)

• Primary citation: Krishnan, S.,Miller, R.M.,Tian, B.,Mullins, R.D.,Jacobson, M.P.,Taunton, J.; Design of reversible, cysteine-targeted Michael acceptors guided by kinetic and computational analysis.; J.Am.Chem.Soc., 136:12624-12630, 2014; PubMed: 25153195; DOI: 10.1021/ja505194w

Experimental method

X-RAY DIFFRACTION (2.6 Å)