4M8T
RSK2 T493M C-Terminal Kinase Domain in complex with 3-(3-(1H-pyrazol-4-yl)phenyl)-2-cyanoacrylamide
Summary for 4M8T
| Entry DOI | 10.2210/pdb4m8t/pdb |
| Related | 4MAO |
| Descriptor | Ribosomal protein S6 kinase alpha-3, (2E)-2-cyano-3-[3-(1H-pyrazol-4-yl)phenyl]prop-2-enamide, SODIUM ION (3 entities in total) |
| Functional Keywords | protein kinase, phosphorylation, covalent inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Mus musculus (mouse) |
| Cellular location | Nucleus : P18654 |
| Total number of polymer chains | 1 |
| Total formula weight | 40358.88 |
| Authors | Miller, R.M.,Taunton, J. (deposition date: 2013-08-13, release date: 2014-10-22, Last modification date: 2014-11-26) |
| Primary citation | London, N.,Miller, R.M.,Krishnan, S.,Uchida, K.,Irwin, J.J.,Eidam, O.,Gibold, L.,Cimermancic, P.,Bonnet, R.,Shoichet, B.K.,Taunton, J. Covalent docking of large libraries for the discovery of chemical probes. Nat.Chem.Biol., 10:1066-1072, 2014 Cited by PubMed: 25344815DOI: 10.1038/nchembio.1666 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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